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OtherBASIC SCIENCE INVESTIGATIONS

Evaluation of the Metabotropic Glutamate Receptor Subtype 5 Using PET and 11C-ABP688: Assessment of Methods

Valerie Treyer, Johannes Streffer, Matthias T. Wyss, Andrea Bettio, Simon M. Ametamey, Uta Fischer, Mark Schmidt, Fabrizio Gasparini, Christoph Hock and Alfred Buck
Journal of Nuclear Medicine July 2007, 48 (7) 1207-1215; DOI: https://doi.org/10.2967/jnumed.107.039578
Valerie Treyer
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Johannes Streffer
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Matthias T. Wyss
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Andrea Bettio
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Simon M. Ametamey
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Uta Fischer
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Mark Schmidt
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Fabrizio Gasparini
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Christoph Hock
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Alfred Buck
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Article Information

vol. 48 no. 7 1207-1215
DOI 
https://doi.org/10.2967/jnumed.107.039578
PubMed 
17574984

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 4, 2007
  • Accepted for publication March 23, 2007
  • Published online July 2, 2007.

Article Versions

  • previous version (June 15, 2007 - 09:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2007 by Society of Nuclear Medicine

Author Information

  1. Valerie Treyer 1 ,
  2. Johannes Streffer 2 ,
  3. Matthias T. Wyss 1 ,
  4. Andrea Bettio 3 ,
  5. Simon M. Ametamey 3 ,
  6. Uta Fischer 2 ,
  7. Mark Schmidt 4 ,
  8. Fabrizio Gasparini 5 ,
  9. Christoph Hock 2 and
  10. Alfred Buck 1
  1. 1PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland; 2Division of Psychiatry Research, University of Zurich, Zurich, Switzerland; 3Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Zurich, Switzerland; 4Novartis Pharma AG, Basel, Switzerland; and 5Novartis Institutes for Biomedical Research, Basel, Switzerland
  1. For correspondence or reprints contact: Alfred Buck, MD, University Hospital Zurich, Division of Nuclear Medicine, Rämistrasse 100, 8091 Zurich, Switzerland. E-mail: fred.buck{at}usz.ch
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  • Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [ 11 C]ABP688 positron emission tomography
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  • In Vivo Ketamine-Induced Changes in [ 11 C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5
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Journal of Nuclear Medicine: 48 (7)
Journal of Nuclear Medicine
Vol. 48, Issue 7
July 2007
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Evaluation of the Metabotropic Glutamate Receptor Subtype 5 Using PET and 11C-ABP688: Assessment of Methods
Valerie Treyer, Johannes Streffer, Matthias T. Wyss, Andrea Bettio, Simon M. Ametamey, Uta Fischer, Mark Schmidt, Fabrizio Gasparini, Christoph Hock, Alfred Buck
Journal of Nuclear Medicine Jul 2007, 48 (7) 1207-1215; DOI: 10.2967/jnumed.107.039578

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Evaluation of the Metabotropic Glutamate Receptor Subtype 5 Using PET and 11C-ABP688: Assessment of Methods
Valerie Treyer, Johannes Streffer, Matthias T. Wyss, Andrea Bettio, Simon M. Ametamey, Uta Fischer, Mark Schmidt, Fabrizio Gasparini, Christoph Hock, Alfred Buck
Journal of Nuclear Medicine Jul 2007, 48 (7) 1207-1215; DOI: 10.2967/jnumed.107.039578
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  • Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation
  • Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a "Molecular Switch" in PAM Pharmacology
  • Marked global reduction in mGluR5 receptor binding in smokers and ex-smokers determined by [11C]ABP688 positron emission tomography
  • Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans
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