Article Figures & Data
Figures
- FIGURE 1.
18F-FDG PET in lymph node staging of lung cancer: unaffected lymph nodes (N0), peribronchial or hilar lymph node involvement (N1), ipsilateral mediastinal and subcarinal involvement (N2), and contralateral and supraclavicular involvement (N3).
- FIGURE 2.
Comparison of maximum SUV in mediastinal lymph nodes. FN = false-negative; TN = true-negative; FP = false-positive; TP = true-positive.
- FIGURE 3.
ROC curves for semiquantitative SUV analysis and visual interpretation of 18F-FDG PET images for mediastinal lymph node staging in patients with lung cancer. Intensity of lesion was visually compared with that of mediastinal blood pool and scored from + + + to − − −.
- FIGURE 4.
Error rates and diagnostic accuracy of lymph node characterization by 18F-FDG PET as function of SUV threshold applied.
Tables
- TABLE 1
Results of Characterization of Mediastinal Lymph Nodes by Visual Interpretation of 18F-FDG PET and Correlation with Pathologic Diagnosis
18F-FDG PET (visual interpretation) All lymph nodes Lung cancer patients Status Negative Positive Total Negative Positive Total Benign 243 TN 58 FP 301 205 TN 36 FP 241 Metastasis 6 FN 64 TP 70 6 FN 64 TP 70 Total 249 122 371 211 100 311 FN = false-negative; TN =true-negative; FP = false-positive; TP = true-positive.
- TABLE 2
Diagnostic Performance of 18F-FDG PET in Assessment of Mediastinal Lymph Nodes of Lung Cancer
Index Visual interpretation (%) SUV cutoff of 2.5 (%) Sensitivity 91 (85–98) 89 (81–96) Specificity 85 (81–90) 84 (79–88) Accuracy 87 (82–91) 85 (81–89) Positive predictive value 64 (55–73) 61 (52–71) Negative predictive value 97 (95–99) 96 (94–99) Values in parentheses are 95% confidence intervals.
- TABLE 3
Results of Characterization of Mediastinal Lymph Nodes by SUV Analysis of 18F-FDG PET and Correlation with Pathologic Diagnosis
18F-FDG PET (semiquantitative analysis) All lymph nodes Lung cancer patients Status SUV < 2.5 SUV ≥ 2.5 Total SUV < 2.5 SUV ≥ 2.5 Total Benign 238 TN 63 FP 301 202 TN 39 FP 241 Metastasis 8 FN 62 TP 70 8 FN 62 TP 70 Total 246 125 371 210 101 311 FN = false-negative; TN =true-negative; FP = false-positive; TP = true-positive.
SUV threshold of 2.5 was used for differentiation between benign and metastatic lymph nodes.
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