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Journal of Nuclear Medicine

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OtherClinical Investigations

Whole-Body 18F-FDG PET in Recurrent or Metastatic Nasopharyngeal Carcinoma

Ruoh-Fang Yen, Ruey-Long Hong, Kai-Yuan Tzen, Mei-Hsiu Pan and Tony Hsiu-Hsi Chen
Journal of Nuclear Medicine May 2005, 46 (5) 770-774;
Ruoh-Fang Yen
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Ruey-Long Hong
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Kai-Yuan Tzen
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Mei-Hsiu Pan
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Tony Hsiu-Hsi Chen
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  • FIGURE 1.
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    FIGURE 1.

    18F-FDG PET images of 51-y-old male patient who underwent PET examination 8 mo after CCRT (pretherapy stage IVA) show a biopsy-proven cervical lymph node metastasis at left submandibular region (arrows) and intense 18F-FDG uptake in right cervical muscle (arrowhead). No lymph node metastasis in the right neck was observed during clinical follow-up in this patient.

  • FIGURE 2.
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    FIGURE 2.

    Image of 63-y-old male patient who underwent 18F-FDG PET examination 8 mo after completion of CCRT reveals multiple 18F-FDG hypermetabolic lesions in right neck, mediastinum, and bilateral lungs. Patient died 13 mo after PET study.

  • FIGURE 3.
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    FIGURE 3.

    Survival for PET-positive and PET-negative patient groups (A) and stage I, II and stage III, IV patient groups (B).

Tables

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    TABLE 1

    Patient Characteristics According to 18F-FDG PET Results

    VariablePET
    Negative 28/64 (44)Positive 36/64 (56)
    Age (y)42.79 ± 12.7549.19 ± 11.78
    Sex
        Male2129
        Female77
    Initial stage
        I and II55
        III and IV2331
    Duration after therapy (mo)14.68 ± 14.7313.58 ± 13.11
    Follow-up
        Censored2828
        Endpoint08
    Survival (mo) after PET36.99 ± 14.6224.83 ± 16.21
    • Values in parentheses are percentage.

    • View popup
    TABLE 2

    Individual Clinical Outcomes According to 18F-FDG PET Results

    Outcome of follow-upPET
    Negative (n = 28)Positive (n = 36)
    No recurrence or metastasis253
    Local recurrence011
    Neck LN metastasis11
    Local recurrence + neck LN metastases09
    Distant metastases28
        Axillary and mediastinal LNs01
        Lung13
        Pericardium10
        Bones04
    Neck LN + lung metastases02
    Second malignancy (nonsmall cell lung carcinoma)01
    Local recurrence + neck LN + lung or bone metastases01
    • LN = lymph node.

    • View popup
    TABLE 3

    Diagnostic Value of 18F-FDG PET in Detection of Recurrence or Metastatic NPCs and Secondary Primary Cancers for 64 NPC Patients

    Follow-up resultsPET results
    PositiveNegativeTotal
    R/M positive33336
    R/M negative32528
    Total362864
    • R/M = recurrence or metastases.

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Journal of Nuclear Medicine: 46 (5)
Journal of Nuclear Medicine
Vol. 46, Issue 5
May 1, 2005
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Whole-Body 18F-FDG PET in Recurrent or Metastatic Nasopharyngeal Carcinoma
Ruoh-Fang Yen, Ruey-Long Hong, Kai-Yuan Tzen, Mei-Hsiu Pan, Tony Hsiu-Hsi Chen
Journal of Nuclear Medicine May 2005, 46 (5) 770-774;

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Whole-Body 18F-FDG PET in Recurrent or Metastatic Nasopharyngeal Carcinoma
Ruoh-Fang Yen, Ruey-Long Hong, Kai-Yuan Tzen, Mei-Hsiu Pan, Tony Hsiu-Hsi Chen
Journal of Nuclear Medicine May 2005, 46 (5) 770-774;
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  • 18F-FDG PET/CT for the Diagnosis of Residual or Recurrent Nasopharyngeal Carcinoma After Radiotherapy: A Metaanalysis
  • The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis
  • PET scanning and Gamma Knife(R) radiosurgery in the early diagnosis and salvage "cure" of locally recurrent nasopharyngeal carcinoma
  • Utility of 18F-FDG PET/CT Uptake Patterns in Waldeyer's Ring for Differentiating Benign from Malignant Lesions in Lateral Pharyngeal Recess of Nasopharynx
  • Differential Roles of 18F-FDG PET in Patients with Locoregional Advanced Nasopharyngeal Carcinoma After Primary Curative Therapy: Response Evaluation and Impact on Management
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