Antimicrobial Peptide 99mTc-Ubiquicidin 29–41 as Human Infection-Imaging Agent: Clinical Trial

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FIGURE 1.
Processing page for calculation of T/NT.
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FIGURE 2.
Anterior whole-body image at 30 min after tracer injection showing kidneys (dotted arrow), liver (solid arrow), and urinary bladder (ball arrow).
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FIGURE 3.
Scintigraphic biodistribution of ^99mTc-UBI 29–41. Percentage injected dose (%ID) data for organs are mean of 3 data points, taking whole-body counts as 100% of injected dose at each interval.
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FIGURE 4.
Positive ^99mTc-UBI 29–41 scintigraphy findings in patient with infection in medial aspect of right hand. Markedly greater focal tracer accumulation is seen on side with infection (arrows) than on normal contralateral side. Tracer uptake is maximal on image obtained at 30 min.
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FIGURE 5.
(A) Focally increased ^99mTc-MDP uptake during skeletal phase in upper femoral shaft (solid arrow) and tip of hip prosthesis (dotted arrow). (B–D) ^99mTc-UBI 29–41 scintigrams obtained at 30 min (B), 60 min (C), and 120 min (D) show no tracer uptake to rule out infection at these sites. Urinary bladder is shielded in image obtained at 120 min.
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FIGURE 6.
T/NTs at different intervals in 18 patients examined with infection imaging.

TABLE 1

Biodistribution Data

Patient no.	%ID in soft tissues					%ID in kidneys					%ID in liver
Patient no.		30 min	120 min	240 min	30 min	120 min	240 min	30 min	120 min	240 min	30 min	120 min	240 min
1	0.51	0.30	0.24	6.50	4.01	2.89	5.63	2.95	2.08	3.62	21.12	34.45
2	0.47	0.28	0.20	7.15	4.45	3.28	4.59	3.45	1.70	5.40	25.60	39.81
3	0.64	0.36	0.24	5.96	5.15	3.97	6.08	3.12	2.29	4.90	22.23	42.30
Mean ± SD	0.54 ± 0.09	0.31 ± 0.04	0.23 ± 0.02	6.53 ± 0.58	4.54 ± 0.57	3.38 ± 0.55	5.43 ± 0.76	3.17 ± 0.25	2.02 ± 0.30	4.60 ± 0.92	23.00 ± 2.32	38.85 ± 4.01

TABLE 2

T/NTs at 30, 60, and 120 Minutes

Patient no.	Type of infection	T/NT					Diagnostic criteria	Visual score
Patient no.	Type of infection			30 min	60 min	120 min	Diagnostic criteria	Visual score
1	Soft tissue	1.12	1.05	0.93	Major	1
2	Soft tissue	1.41	1.30	1.30	Major	1
3	Soft tissue	1.34	1.26	1.28	Major	0
4	Chronic osteomyelitis	2.74	2.08	1.85	Minor	3
5	Soft tissue	2.09	1.83	1.79	Major	3
6	Soft tissue	1.61	1.45	1.35	Major	2
7	Soft tissue	2.65	2.38	2.30	Major	3
8	Soft tissue	1.71	1.67	1.76	Major	2
9	Acute osteomyelitis	5.39	4.56	3.99	Minor	3
10	Soft tissue	2.21	1.55	1.56	Major	3
11	Soft tissue	1.70	1.66	1.68	Major	2
12	Acute osteomyelitis	4.21	3.99	2.68	Minor	3
13	Prosthesis loosening	1.26	1.18	1.20	Minor	0
14	Soft tissue	2.12	1.65	1.66	Major	2
15	Soft tissue	5.23	4.32	4.08	Major	3
16	Soft tissue	1.51	1.49	1.50	Major	2
17	Soft tissue	1.96	1.74	1.60	Major	2
18	Soft tissue	6.03	3.97	2.50	Major	3
Mean ± SD			2.75 ± 1.69	2.30 ± 1.30	2.04 ± 1.01