Improvement of Cardiac Sympathetic Innervation by Renal Transplantation

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FIGURE 1.
Individual data of 13 CRF patients: ¹²³I-MIBG washout rate, late H/M ¹²³I-MIBG activity ratio, and SDANN before and after renal transplantation. After transplantation, washout rate significantly decreased (P = 0.006), late H/M ratio significantly increased (P = 0.006), and SDANN did not significantly increase (P = 0.24). Data are expressed as mean ± SD.

TABLE 1

Patient Characteristics

Patient no.	Age (y)	Sex	Basic renal disease	Duration of dialysis	HT	DM	Heart disease
1	25	M	Glomerulonephritis	1 y 8 mo	+	−	Dilated cardiomyopathy
2	9	M	Glomerulonephritis	9 y	−	−	−
3	24	F	Pyelonephritis	1 y 2 mo	−	−	−
4	46	M	Glomerulonephritis	3 y	+	−	−
5	43	F	Pyelonephritis	10 y	−	−	−
6	26	M	Glomerulonephritis	3 mo	+	−	−
7	55	M	Diabetic nephropathy	1 y 5 mo	+	+	Prior inferior infarction
8	23	M	Glomerulonephritis	1 y 5 mo	+	−	Dilated cardiomyopathy
9	40	F	Glomerulonephritis	3 y 6 mo	+	−	−
10	43	M	Glomerulonephritis	4 y 3 mo	+	+	−
11	27	M	Glomerulonephritis	11 y 6 mo	+	−	−
12	27	M	Glomerulonephritis	6 y	+	−	−
13	33	F	Glomerulonephritis	5 y	+	−	−

TABLE 2

Comparisons Between Control Subjects, Patients Before Renal Transplantation, and Patients After Renal Transplantation

Variable	Control subjects	Patients			P*	P^†	P^‡
Variable	Control subjects			Before	P*	P^†	P^‡	After
HRV
mNN (ms)	795 ± 36	752 ± 112	721 ± 119	0.22	0.22	0.052
SDNN (ms)	161 ± 17	100 ± 45	114 ± 49	<0.001	0.25	0.006
SDANN (ms)	153 ± 19	92 ± 45	107 ± 48	<0.001	0.24	0.006
SDNN index (ms)	62 ± 11	36 ± 13	36 ± 15	<0.001	0.75	<0.001
rMSSD (ms)	35 ± 8	16 ± 6	22 ± 19	<0.001	0.97	0.001
LF power (ln[ms²])	6.47 ± 0.34	4.87 ± 1.20	4.79 ± 0.94	<0.001	0.71	<0.001
HF power (ln[ms²])	5.35 ± 0.43	3.39 ± 1.01	3.49 ± 0.99	<0.001	0.71	<0.001
Normalized LF power	0.39 ± 0.10	0.33 ± 0.12	0.32 ± 0.07	0.19	0.77	0.063
Normalized HF power	0.13 ± 0.04	0.08 ± 0.04	0.09 ± 0.04	0.009	0.23	0.048
LF/HF ratio	3.20 ± 0.98	5.36 ± 3.55	4.26 ± 2.30	0.24	0.054	0.154
MIBG
Early H/M ratio	2.31 ± 0.31	1.97 ± 0.30	1.99 ± 0.25	0.016	0.92	0.013
Late H/M ratio	2.69 ± 0.30	1.74 ± 0.39	2.06 ± 0.39	<0.001	0.006	<0.001
Washout rate (%)	5 ± 8	46 ± 21	20 ± 22	<0.001	0.006	0.040