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Journal of Nuclear Medicine

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OtherClinical Investigations

Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer’s Disease

Georges El Fakhri, Marie Foley Kijewski, Marilyn S. Albert, Keith A. Johnson and Stephen C. Moore
Journal of Nuclear Medicine December 2004, 45 (12) 2026-2031;
Georges El Fakhri
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Marie Foley Kijewski
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Marilyn S. Albert
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Keith A. Johnson
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Stephen C. Moore
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Figures

  • FIGURE 1.
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    FIGURE 1.

    Locations of 6 VOIs defined on MR images used in SPECT-based discrimination tasks. (A) Banks of superior temporal sulcus (red). (B) Basal forebrain (orange) and amygdala (blue). (C) Rostral anterior cingulate gyrus (orange), caudal anterior cingulate gyrus (blue), and posterior cingulate gyrus (white).

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    FIGURE 2.

    General spectral energy weights optimized on the basis of the accuracy and precision of simultaneous estimations of lesion and background activities.

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    FIGURE 3.

    Transverse slice of a converter study reconstructed with STD, QUANunif, and QUANnonunif.

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    FIGURE 4.

    Fitted ROC curves obtained for discrimination between questionable and converter groups by use of QUANnonunif and 7, 11, 13, 15, and 19 iterations (it).

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    FIGURE 5.

    Correlated ROC curves obtained for discrimination between normal and converter groups by use of OSEM with QUANunif, OSEM with QUANnonunif, filtered backprojection with a uniform attenuation map (STD), and MRI data.

  • FIGURE 6.
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    FIGURE 6.

    Correlated ROC curves obtained for discrimination between normal and questionable groups by use of QUANunif, QUANnonunif, STD, and MRI data.

  • FIGURE 7.
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    FIGURE 7.

    Correlated ROC curves obtained for discrimination between questionable and converter groups by use of QUANunif, QUANnonunif, STD, and MRI data.

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Journal of Nuclear Medicine: 45 (12)
Journal of Nuclear Medicine
Vol. 45, Issue 12
December 1, 2004
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Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer’s Disease
Georges El Fakhri, Marie Foley Kijewski, Marilyn S. Albert, Keith A. Johnson, Stephen C. Moore
Journal of Nuclear Medicine Dec 2004, 45 (12) 2026-2031;

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Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer’s Disease
Georges El Fakhri, Marie Foley Kijewski, Marilyn S. Albert, Keith A. Johnson, Stephen C. Moore
Journal of Nuclear Medicine Dec 2004, 45 (12) 2026-2031;
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