Article Figures & Data
Figures
- FIGURE 1.
Typical testicular sections from subject In2 (A) and subject In4 (B), administered intravenously with 111In chloride.
- FIGURE 2.
Typical testicular sections from subject Tl1 (A) and subject Tl2 (B), administered intravenously with 201Tl chloride.
Tables
Subject Time of administration before orchidectomy (h) Total sub-capsular testis weight (g) (both testes) Subject weight (kg) %IA/g (nonspecific) %IA/g (mean ± SE) gross testis %IA/g (mean ± SE) seminiferous tubules %IA/g (mean (1, 2))* epididymis %IA/mL (mean (1, 2))* blood In1 24.5 17.8 55 0.0018 0.0070 ± 0.0007 0.0050 ± 0.0005 0.0025 0.0080 (1 sample) (0.0078, 0.0082) In2 25.0 39 73 0.0014 0.0069 ± 0.0001 0.0036 ± 0.0002 0.0032 0.0074 (1 sample) (0.0072, 0.0076) In3 24.0 27.6 46 0.0022 0.0052 ± 0.0002 0.0022 ± 0.0004 0.0039 0.006 (0.0036, 0.0042) (0.0059, 0.0061) In4 25.0 28.2 71 0.0014 0.0043 ± 0.0013 0.0031 ± 0.0003 0.0018 0.0021 (0.0017, 0.0019) (0.0019, 0.0023) In5 46.5 20.6 103 0.0010 0.0044 ± 0.0022 0.0022 ± 0.0001 0.0031 0.0042 (0.0027, 0.0035) (0.0040, 0.0044) In6 47.0 42.0 120 0.0008 0.0023 ± 0.0001 0.0010 ± 0.0001 0.0017 0.0021 (1 sample) (0.0021, 0.0021) ↵* (1, 2) are individual of 2 samples for each subject when only 2 samples were obtained.
Subject Time of administration before orchidectomy (h) Total subcapsular testis weight (g) (both testes) Subject weight (kg) %IA/g (nonspecific) %IA/g (mean ± SE) gross testis %IA/g (mean ± SE) seminiferous tubules %IA/mL (mean (1, 2))* blood Tl1 25.0 41.0 72 0.0014 0.0060 ± 0.0002 0.0050 ± 0.0002 0.00010 (0.0001, 0.0001) Tl2 24.5 15.0 69 0.0015 0.0060 ± 0.0010 0.0020 ± 0.0001 0.00020 (0.0002, 0.0002) Tl3 22.3 23.8 78 0.0013 0.0050 ± 0.0006 0.0040 ± 0.0001 0.00010 (0.00009, 0.00011) Tl4 25.7 29.2 76 0.0013 0.0051 ± 0.0001 0.0030 ± 0.0002 0.00020 (0.00017, 0.00023) Tl5 45.0 21.4 70 0.0014 0.0052 ± 0.0002 0.0032 ± 0.0001 0.00010 (1 sample) Tl6 47.0 12.4 60 0.0017 0.0050 ± 0.0009 0.0026 ± 0.0007 0.00020 (1 sample) ↵* (1, 2) are individual of 2 samples for each subject when only 2 samples were obtained. No results for epididymis.
- TABLE 3
Summary Results for 111ln Chloride: Concentration Above Levels Expected for Nonspecific Uptake as Proportion of Body Mass
Mean injection time before surgery (h) %IA/g of gross testicular tissue (mean ± SE) %IA into testes* (mean ± SE) Multiple of nonspecific %IA/g of tissue (mean ± SE or (1, 2)†) Gross testicular tissue Seminiferous tubules Epididymis Blood 24.6 0.0058 ± 0.0007 0.20 ± 0.02 3.56 ± 0.55 2.14 ± 0.40 1.68 ± 0.23 3.49 ± 0.85 46.8 0.0033 0.12 3.64 1.73 2.61 3.41 (0.0044, 0.0023) (0.15, 0.08) (4.40, 2.88) (2.20, 1.26) (3.10, 2.12) (4.20, 2.62) - TABLE 4
Summary Results for 201TI Chloride: Concentration Above Levels Expected for Nonspecific Uptake as Proportion of Body Mass
Mean injection time before surgery (h) %IA/g of gross testicular tissue (mean ± SE) %IA into testes* (mean ± SE) Multiple of nonspecific %IA/g of tissue (mean ± SE or (1, 2)†) Gross testicular tissue Seminiferous tubules Blood 24.4 0.0055 ± 0.0003 0.19 ± 0.01 4.01 ± 0.09 2.57 ± 0.49 0.11 ± 0.02 46.0 0.0051 0.18 3.32 1.9 0.09 (0.0052, 0.005) (0.18, 0.17) (3.70, 2.94) (2.28, 1.52) (0.07, 0.11) - TABLE 5
Values of Absorbed Dose to Testes and Effective Dose for 111ln Chloride Using Different Models of Biologic Clearance from Testis
Model Testicular self-dose (mGy/MBq) Total testicular absorbed dose (mGy/MBq) Effective dose (mSv/MBq) ICRP (17,30,31) 0.015 0.053 0.21 This work Model I 0.134 ± 0.013 0.172 ± 0.013 0.22 ± 0.001 Model II 0.168 ± 0.017 0.206 ± 0.017 0.22 ± 0.002 Model III 0.096 ± 0.014 0.135 ± 0.014 0.22 ± 0.001 - TABLE 6
Values of Absorbed Dose to Testes and Effective Dose for 201Tl Chloride Using Different Models of Biologic Clearance from Testis
Model Testicular self-dose (mGy/MBq) Total testicular absorbed dose (mGy/MBq) Effective dose (mSv/MBq) ICRP (30,32) 0.442 0.45 0.17 This work Model I 0.105 ± 0.006 0.113 ± 0.006 0.14 ± 0.001 Model II 0.136 ± 0.007 0.144 ± 0.007 0.14 ± 0.001 Model III 0.111 ± 0.016 0.118 ± 0.016 0.14 ± 0.002 - TABLE 7
Comparison of Results for Uptake of 111ln and 201Tl From Our Research with Those Reported in Other Studies
Reference Radionuclide Measurement time after administration (h) Model No. of subjects %IA into testes Hoyes et al. (20) 114mln 24 Rat 6 0.2 This work 111ln 24 Human 4 0.20 This work 111ln 48 Human 2 0.12 Rao et al. (5) 201Tl 24 Human (imaging) 4 0.46 Atkins et al. (14) 201Tl 24 Human (imaging) 3 0.15 Hosain and Hosain (15) 201Tl 24 Human (imaging) 0.8 Gupta et al. (18) 201Tl 24 Human (imaging) 1.0 Samson et al. (19) 201Tl Unknown Human (postmortem) 2 0.11 Atkins et al. (14) 201Tl 24 Dog 1 0.7 This work 201Tl 24 Human 4 0.19 This work 201Tl 48 Human 2 0.18
