OtherBasic Science Investigations

A Bivalent Leukotriene B4 Antagonist for Scintigraphic Imaging of Infectious Foci

Julliëtte E.M. van Eerd, Wim J.G. Oyen, Thomas D. Harris, Huub J.J.M. Rennen, D. Scott Edwards, Shuang Liu, Charles E. Ellars, Frans H.M. Corstens and Otto C. Boerman
Journal of Nuclear Medicine July 2003, 44 (7) 1087-1091;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Structural formula of DPC11870-11.

  • FIGURE 2.
    FIGURE 2.

    HPLC radiogram of 111In-DPC11870-11 using C18 RP-HPLC column eluted with 5%/min acetonitrile gradient.

  • FIGURE 3.
    FIGURE 3.

    (A) Scintigraphic images of E. coli infection in thigh muscle of a rabbit. The rabbit received 11 MBq of 111In-DPC11870-11 (3 μg) intravenously. Anterior images (from left to right) were acquired immediately and at 2, 6, and 24 h after injection of 111In-DPC11870-11. (B) Scintigraphic image of rabbit that received 2 mg of nonradioactive indium-DPC11870-11 before injection of 111In-labeled LTB4 antagonist. This anterior image was acquired 6 h after injection of radiolabel.

  • FIGURE 4.
    FIGURE 4.

    Biodistribution data obtained 6 h after injection of 111In-DPC11870-11. Each bar represents mean value ± SD. Values were analyzed using unpaired t test. *P < 0.05 and **P < 0.01 for differences in uptake of radiolabel between rabbits injected also with 2 mg of nonradioactive LTB4 antagonist and rabbits injected only with radiolabeled compound (3 μg).

  • FIGURE 5.
    FIGURE 5.

    Blood clearance of 111In-DPC11870-11 in New Zealand White rabbits. Average amount and SD of activity for 2 rabbits are expressed as %ID/g present in blood and plasma. Plasma concentration was corrected using hematocrit of animals.

  • FIGURE 6.
    FIGURE 6.

    White blood cell counts after injection of 111In-DPC11870-11. Initial amount of white blood cells is represented as 100%. Number of cells determined after injection is calculated as percentage of this initial value.

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