Article Figures & Data
Figures
- FIGURE 1.
Chemical structure of 4-125I-mTyr.
- FIGURE 2.
Biodistribution of 4-125I-mTyr compared with that of 125I-IMT in mice. (A) Blood clearance. (B) Kidney radioactivity. Each bar represents mean ± SD of 5 animals.
- FIGURE 3.
Urinary excretion of 4-125I-mTyr and effects of probenecid administration in mice. Control compared with probenecid administration. Each bar represents mean ± SD of 5 animals. *P < 0.05; **P < 0.005.
- FIGURE 4.
Comparison of 4-125I-mTyr (A) and 125I-IMT (B) accumulation in mouse kidney with or without probenecid administration. (Left) Photograph. (Center) Superimposed. (Right) Autoradiograph.
- FIGURE 5.
Effects of inhibitors on accumulation of 4-125I-mTyr (A) l-14C(U)-Tyr (B), and 125I-IMT (C) in LLC-PK1 cell monolayers. Each column represents mean ± SD of 4 monolayers. *P < 0.01; **P < 0.05.
Tables
Biodistribution 5 min 15 min 30 min Blood* 3.72 ± 0.40 1.56 ± 0.36 0.45 ± 0.09 Brain 0.61 ± 0.16 0.47 ± 0.07 0.32 ± 0.08 Pancreas 25.44 ± 1.85 14.03 ± 3.69 2.00 ± 0.57 Liver 4.31 ± 0.51 1.80 ± 0.42 0.64 ± 0.16 Stomach 1.24 ± 0.22 1.05 ± 0.37 2.82 ± 2.27 Intestine 2.26 ± 0.29 1.03 ± 0.26 0.56 ± 0.06 Kidney 23.77 ± 4.89 12.89 ± 9.53 4.24 ± 1.92 Heart 2.51 ± 0.33 1.42 ± 0.34 0.92 ± 0.36 Lung 3.76 ± 0.52 1.90 ± 0.41 0.74 ± 0.14 Spleen 4.04 ± 0.64 2.35 ± 1.05 0.54 ± 0.17 ↵* %ID/mL blood (n = 5 mice).
All data except blood are expressed as %ID/g tissue, mean ± 1 SD.
Biodistribution 5 min 15 min 30 min Blood* 6.70 ± 1.44 3.12 ± 0.43 1.47 ± 0.08 Brain 0.58 ± 0.12 0.47 ± 0.08 1.05 ± 0.13 Pancreas 41.48 ± 5.16 25.84 ± 9.50 9.18 ± 1.89 Liver 4.63 ± 1.29 2.00 ± 0.15 0.93 ± 0.03 Stomach 4.31 ± 1.66 4.81 ± 1.39 2.93 ± 0.28 Intestine 5.08 ± 1.21 2.49 ± 0.65 0.91 ± 0.06 Kidney 102.62 ± 0.93 75.34 ± 15.74 24.05 ± 6.04 Heart 5.67 ± 2.16 3.10 ± 0.41 1.53 ± 0.08 ↵* %ID/mL blood (n = 5 mice).
All data except blood are expressed as %ID/g tissue, mean ± 1 SD.
