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OtherBasic Science Investigations

Quantitative Cholescintigraphy: Selection of Random Dose for CCK-33 and Reproducibility of Abnormal Results

Vicente Pons, Ramón Sopena, Melchor Hoyos, Vicente Garrigues, Carmen Cano, Pilar Nos and Julio Ponce
Journal of Nuclear Medicine March 2003, 44 (3) 446-450;
Vicente Pons
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Ramón Sopena
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Melchor Hoyos
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Vicente Garrigues
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Carmen Cano
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Pilar Nos
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Julio Ponce
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    FIGURE 1.

    Graphic representation of LP (A), EP (B), and EF (C) for CCK-1 and CCK-2 doses. Only the data corresponding to those for patients with an abnormal EF (≤40%) in the first study are shown. Horizontal bars represent mean values.

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    TABLE 1

    Characteristics of 4 Groups for Analyzing Effects of CCK Doses on Gallbladder Dynamics, LP, EP, and EF

    GroupWomen/men (n)Mean age (range) (y)CCK doseInfusion time (min)Mean (SD)IDU/kg/min
    IDU/kgng/kgLP (min)EP (min)EF (%)
    I4/631 (18–50)0.251.9234 (2)12 (3)42.9 (19.4)0.08
    II5/542 (30–66)0.302.3154 (2)27 (4)†58.4 (26.0)0.02
    III6/434 (29–47)0.403.07204 (2)30 (5)†68.3 (18.1)†0.02
    IV6/442 (28–65)0.604.6304 (2)39 (4)‡77.5 (25.0)†0.02
    Total21/1937 (18–66)
    • ↵† P < 0.05 vs. group I.

    • ↵‡ P < 0.05 vs. groups I and II.

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    TABLE 2

    LP, EP, and EF in Groups Studied in Phase 2 (n = 33)

    ParameterMean (SD)Range
    LP (min)4 (2)2–12
    EP (min)28 (6)14–35
    EF (%)74.2 (17.1)38–96
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    TABLE 3

    LP, EP, and EF in 2 Studies of Phase 3 (CCK-1 and CCK-2 doses) for 44 Patients Each

    DoseMean (SD)
    LP (min)EP (min)EF (%)
    CCK-15.2 (3.7)27.8 (8.9)25.2 (8.2)
    CCK-25.0 (3.5)28.9 (8.1)31.1 (17.7)
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Journal of Nuclear Medicine
Vol. 44, Issue 3
March 1, 2003
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Quantitative Cholescintigraphy: Selection of Random Dose for CCK-33 and Reproducibility of Abnormal Results
Vicente Pons, Ramón Sopena, Melchor Hoyos, Vicente Garrigues, Carmen Cano, Pilar Nos, Julio Ponce
Journal of Nuclear Medicine Mar 2003, 44 (3) 446-450;

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Quantitative Cholescintigraphy: Selection of Random Dose for CCK-33 and Reproducibility of Abnormal Results
Vicente Pons, Ramón Sopena, Melchor Hoyos, Vicente Garrigues, Carmen Cano, Pilar Nos, Julio Ponce
Journal of Nuclear Medicine Mar 2003, 44 (3) 446-450;
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