l-1-11C-Tyrosine PET in Patients with Laryngeal Carcinomas: Comparison of Standardized Uptake Value and Protein Synthesis Rate

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FIGURE 1.
Transaxial CT (A) and TYR PET (B) scans of T2 N2 M0 supraglottic laryngeal carcinoma (patient 13). Tumor (1) and metastatic lymph node (2) are clearly visualized. Note relatively low uptake of TYR in central necrosis of lymph node.
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FIGURE 2.
Linear curve fits for relationship between PSR and SUV_BW, SUV_BSA, SUV_LBM, and SUV_QI. Significant correlations (P > 0.001; 2-tailed Pearson test) were observed between PSR and SUV corrected for BW (r = 0.87), BSA (r = 0.87), LBM (r = 0.90), and QI (r = 0.84).

TABLE 1

Patient Characteristics, TNM Stage, and TYR PET Data

Patient no.	Sex	Age (y)	TNM	PSR	SUV_BW	SUV_BSA	SUV_LBM	SUV_QI
1	M	60	T1 N0 M0	0.72	1.42	0.44	1.31	0.57
2	M	58	T1 N0 M0	0.89	1.60	0.51	1.49	0.52
3	M	72	T1 N0 M0	1.14	2.43	0.60	1.74	0.74
4	M	85	T2 N1 M0	2.50	5.21	1.15	3.13	1.72
5	M	69	T2 N0 M0	1.62	4.46	1.01	2.89	1.50
6	M	73	T2 N0 M0	2.06	3.79	1.00	2.84	1.29
7	M	64	T2 N0 M0	2.19	3.23	0.93	2.47	1.27
8	M	70	T2 N0 M0	1.44	1.85	0.47	1.39	0.56
9	M	69	T2 N0 M0	0.87	2.29	0.65	1.66	0.82
10	M	59	T2 N0 M0	1.58	3.55	0.91	2.73	1.16
11	M	49	T2 N1 M0	1.51	2.91	0.75	2.27	1.04
12	M	49	T2 N0 M0	1.61	4.07	0.98	2.90	1.59
13	M	61	T2 N2 M0	2.48	5.49	1.28	3.47	1.99
14	M	64	T2 N0 M0	1.95	4.26	1.03	2.94	1.55
15	M	81	T2 N0 M0	1.14	4.22	1.05	2.92	1.40
16	M	56	T2 N0 M0	3.14	5.47	1.33	3.99	1.81
17	F	63	T2 N0 M0	1.35	4.00	1.09	2.37	1.64
18	M	58	T2 N0 M0	1.43	2.19	0.53	1.55	0.79
19	M	49	T2 N0 M0	2.28	4.20	1.20	3.50	1.38
20	M	71	T3 N0 M0	3.52	5.56	1.35	3.89	1.78
21	M	85	T3 N2 M0	2.32	5.43	1.04	3.66	2.14
22	M	59	T4 N0 M0	1.38	3.45	1.05	2.85	1.30
23	M	65	T4 N0 M0	4.16	7.37	1.95	5.52	2.67
24	M	66	T4 N0 M0	2.81	5.52	1.48	4.19	1.94
Median				1.64	4.04	1.02	2.87	1.39
Range				0.72–4.16	1.42–7.34	0.44–1.95	1.31–5.52	0.52–2.67