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Journal of Nuclear Medicine

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OtherClinical Investigations

Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch

Wolfgang M. Schaefer, Bernd Nowak, Hans-Juergen Kaiser, Karl-Christian Koch, Stephan Block, Juergen vom Dahl and Udalrich Buell
Journal of Nuclear Medicine January 2003, 44 (1) 33-39;
Wolfgang M. Schaefer
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Bernd Nowak
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Hans-Juergen Kaiser
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Karl-Christian Koch
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Stephan Block
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Juergen vom Dahl
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Udalrich Buell
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  • FIGURE 1.
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    FIGURE 1.

    Definition of 18 myocardial tissue ROIs on 3 representative short-axis slices (apex, midventricular, and base). Left ventricular input (LV-Inp.) ROI is located in basal slice.

  • FIGURE 2.
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    FIGURE 2.

    (A) ROIs with increased volumes but all containing approximately same myocardial mass. (B) ROI volume dependencies of MBF_kin, 99mTc-tetrofosmin uptake, MBF_micr, tissue fraction, and 18F-FDG uptake. All values are expressed as ratios of respective value with A (smallest ROI).

  • FIGURE 3.
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    FIGURE 3.

    Mean MBF_micr (mL·min−1· mL−1) and relative 99mTc-tetrofosmin uptake of investigated 6 segments and of all segments classified as normal (abscissa). 99mTc-tetrofosmin uptake values are normalized to respective patient’s maximum uptake region, set as 100%. Ant = anterior; lat = lateral; post = posterior; seg. = segments; sep = septal.

  • FIGURE 4.
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    FIGURE 4.

    Mean MBF_micr (mL·min−1·mL−1) and relative 99mTc-tetrofosmin uptake in normal myocardium and MPMM myocardium. 99mTc-tetrofosmin uptake values are normalized to respective patient’s maximum uptake region, set as 100%. n. s. = not statistically significant.

  • FIGURE 5.
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    FIGURE 5.

    Segmental MPMM-to-normal percentages of mean MBF_micr and relative 99mTc-tetrofosmin uptake. Mean normal values are set as 100% for each segment for either parameter. n = number of MPMM segments. *P < 0.05. ***P < 0.005. Ant = anterior; lat = lateral; post = posterior; sep = septal.

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Journal of Nuclear Medicine
Vol. 44, Issue 1
January 1, 2003
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Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch
Wolfgang M. Schaefer, Bernd Nowak, Hans-Juergen Kaiser, Karl-Christian Koch, Stephan Block, Juergen vom Dahl, Udalrich Buell
Journal of Nuclear Medicine Jan 2003, 44 (1) 33-39;

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Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch
Wolfgang M. Schaefer, Bernd Nowak, Hans-Juergen Kaiser, Karl-Christian Koch, Stephan Block, Juergen vom Dahl, Udalrich Buell
Journal of Nuclear Medicine Jan 2003, 44 (1) 33-39;
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