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OtherClinical Investigations

Quantitation of Liver and Spleen Uptake of 99mTc-Phytate Colloid Using SPECT: Detection of Liver Cirrhosis

David Groshar, Gleb Slobodin and Eli Zuckerman
Journal of Nuclear Medicine March 2002, 43 (3) 312-317;
David Groshar
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Gleb Slobodin
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Eli Zuckerman
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  • FIGURE 1.
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    FIGURE 1.

    Receiver operating characteristic curves for volume, %ID/cm3, and total uptake for liver and spleen.

  • FIGURE 2.
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    FIGURE 2.

    Relationship between total liver uptake and Child–Pugh chronic liver disease classification. These parameters correlate inversely and are statistically significant.

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    FIGURE 3.

    Relationship between liver volumes and Child–Pugh chronic liver disease classification. These parameters correlate poorly and are statistically significant.

Tables

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    TABLE 1

    Quantitative SPECT Results for Liver and Spleen

    ParameterLiverSpleen
    Volume (cm3)%ID/cm3Uptake (%)Volume (cm3)%ID/cm3Uptake (%)
    Cirrhosis patients1,467 ± 3480.024 ± 0.0135.6 ± 13.5833 ± 4600.033 ± 0.0124.9 ± 12.0
     (n = 60)(1,384/1,590)(0.022/0.027)(32/39)(714/952)(0.029/0.036)(22/28)
    Control patients1,487 ± 3970.044 ± 0.0161.6 ± 10.2239 ± 900.032 ± 0.017.6 ± 3.2
     (n = 36)(1,350/1,585)(0.039/0.049)(58/65)(208/269)(0.029/0.035)(6/9)
    P0.80<0.0001<0.0001<0.00010.88<0.0001
    • Values are mean ± 1 SD; numbers in parentheses are 95% confidence interval for mean.

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    TABLE 2

    Results of ROC Curve Analysis for Detecting Liver Cirrhosis

    ParameterLiverSpleen
    Volume (cm3)%ID/cm3Uptake (%)Volume (cm3)%ID/cm3Uptake (%)
    Sensitivity (%)38  (26/52)70  (57/81)78  (66/88)90  (79/96)33  (22/47)78  (66/88)
    Specificity (%)78  (61/90)94  (81/99)97  (85/99)100  (100/100)83  (67/93)100  (100/100)
    PPV (%)74  (62/85)95  (86/99)98  (91/100)100  (100/100)77  (64/87)100  (100/100)
    NPV (%)43  (27/61)65  (49/81)73  (55/86)86  (70/95)43  (26/60)73  (56/87)
    AUC0.51  (0.41/0.62)0.89  (0.81/0.94)0.94  (0.87/0.94)0.97  (0.91/0.99)0.52  (0.41/0.62)0.93  (0.86/0.97)
    Threshold1,5630.02847.63890.02614.9
    • PPV and NPV = positive and negative predictive values, respectively; AUC = area under curve.

    • Numbers in parentheses are 95% confidence intervals.

    • View popup
    TABLE 3

    Correlation Between Quantitative SPECT and Child–Pugh Score (n = 60)

    ParameterLiverSpleen
    Volume (cm3)%ID/cm3Uptake (%)Volume (cm3)%ID/cm3Uptake (%)
    r−0.26−0.53−0.680.54−0.080.44
    95% CI−0.48/−0.005−0.69/−0.32−0.80/−0.520.32/0.69−0.33/0.170.21/0.62
    P0.046<0.0001<0.0001<0.00010.520.0004
    • 95% CI = 95% CI for correlation coefficient.

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Journal of Nuclear Medicine
Vol. 43, Issue 3
March 1, 2002
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Quantitation of Liver and Spleen Uptake of 99mTc-Phytate Colloid Using SPECT: Detection of Liver Cirrhosis
David Groshar, Gleb Slobodin, Eli Zuckerman
Journal of Nuclear Medicine Mar 2002, 43 (3) 312-317;

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Quantitation of Liver and Spleen Uptake of 99mTc-Phytate Colloid Using SPECT: Detection of Liver Cirrhosis
David Groshar, Gleb Slobodin, Eli Zuckerman
Journal of Nuclear Medicine Mar 2002, 43 (3) 312-317;
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