OtherBasic Science Investigations

Evaluation of 99mTc-Ciprofloxacin Scintigraphy in a Rabbit Model of Staphylococcus aureus Prosthetic Joint Infection

Laure Sarda, Azzam Saleh-Mghir, Can Peker, Alain Meulemans, Anne-Claude Crémieux and Dominique Le Guludec
Journal of Nuclear Medicine February 2002, 43 (2) 239-245;

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    99mTc-ciprofloxacin scintigraphy (images obtained 4 h after injection). (A) Infected rabbit: increasing and expanding 99mTc-ciprofloxacin uptake in right infected prosthetic knee (a) 5 d, (b) 12 d, and (c) 19 d after surgery. (B) Uninfected rabbit: significant, increasing 99mTc-ciprofloxacin uptake in right uninfected prosthetic knee (a) 5 d, (b) 12 d, and (c) 19 d after surgery.

  • FIGURE 2.
    FIGURE 2.

    Autoradiography of knee in infected rabbit. (A) Normal (nonoperated) knee: (a) epiphysial disk cartilage, (b) articular cartilage. (B) Infected prosthetic knee: (c) muscle, (d) articular cartilage, (e) tibial prosthesis, (f) tibial bone. (C) Pus.

  • FIGURE 3.
    FIGURE 3.

    Operated-to-normal-knee activity ratios (ONKR) in G1 (infected) and G2 (uninfected) rabbits according to time after knee arthroplasty.

  • FIGURE 4.
    FIGURE 4.

    99mTc-ciprofloxacin images of uninfected rabbit (A) 1 h, (B) 4 h, and (C) 24 h after 99mTc-ciprofloxacin injection. No decrease in 99mTc-ciprofloxacin uptake is seen in left prosthetic uninfected knee on 24-h images.

  • FIGURE 5.
    FIGURE 5.

    Mean operated-to-normal-knee activity ratios (ONKR) in G1 (infected) and G2 (uninfected) rabbits according to time after injection of 99mTc-ciprofloxacin (regardless of time after surgery).

Tables

  • TABLE 1

    Biodistributions of 99mTc-Ciprofloxacin in Prosthetic and Normal Contralateral Knees of Infected (G1) and Uninfected (G2) Rabbits

    Operated-to-normal-knee tissue uptake ratiosInfected (G1)Uninfected (G2)P
    Thigh muscle2.17 ± 1.451.45 ± 0.87NS
    Femoral articular cartilage2.37 ± 0.773.01 ± 0.56NS
    Upper tibial bone5.64 ± 7.641.15 ± 1.03NS
    Upper tibial bone marrow2.30 ± 2.420.95 ± 0.53NS

    • NS = not significant.

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