Article Figures & Data
Figures
- FIGURE 1.
Summed images (from 7 to 60 min) for 1 subject for 11C-l-deprenyl (H) (top row) and 11C-l-deprenyl-D2 (D) (bottom row). Planes from left to right show heart and lungs (planes 4 and 1); liver, stomach, and spleen (planes 17 and 14); and kidneys (planes 24 and 21). Note reduced accumulation of 11C with 11C-l-deprenyl-D2. Rainbow color scale is used.
- FIGURE 2.
Time-activity curves for 1 subject for kidneys (A), heart (B), lungs (C), spleen (D), liver (E), and stomach (F) after injection of 11C-l-deprenyl (H; •) and 11C-l-deprenyl-D2 (D; ○). Note that maximum value of ordinate for heart, lungs, spleen, liver, and stomach is only half that of kidneys (0.02%/mL vs. 0.04%/mL).
- FIGURE 3.
(A) Time-activity curves for arterial plasma for 11C-l-deprenyl (H; •) and 11C-l-deprenyl-D2 (D; ○). (B) Plasma integral for time-activity curves show that value of arterial plasma input function is greater with deuterium-substituted tracer.
- FIGURE 4.
(A) Bar graph compares plasma-to-brain transfer function (K1) for 11C-l-deprenyl (H; ▪) and 11C-l-deprenyl-D2 (D; □). (B) Bar graph compares λk3, which is index of MAO B activity. Note that values for K1 did not differ except in kidney, which was barely significant (P < 0.04) in contrast to λk3, which showed marked significant reductions in all organs (P < 0.003).
- FIGURE 5.
Plot of ∂Ki/∂λk3(λk3/Ki) vs. λk3 for K1 values of 0.25, 0.50, 1.0, 1.5, 2.0, and 2.5 mL/min/mL. Note that when Ki changes very little with relatively large changes in λk3, uptake is flow limited. With larger values of K1, Ki is sensitive to changes in λk3 over much wider range than for lower values.
Tables
- TABLE 1
Values for IQ and Model Terms for 11C-l-Deprenyl (H) and 11C-l-Deprenyl-D2 (D) Calculated Using 3-Compartment Model
Organ IQ* (mL/min/g) K1† k2 k3‡ λk3* k3/k2‡ Heart (H) 0.43 ± 0.08 0.65 ± 0.13 0.22 ± 0.06 0.49 ± 0.16 1.47 ± 0.41 2.19 ± 0.36 Heart (D) 0.23 ± 0.05 0.65 ± 0.23 0.26 ± 0.05 0.16 ± 0.013 0.39 ± 0.06 0.65 ± 0.14 Lungs (H) 0.095 ± 0.02 2.74 ± 1.60 0.84 ± 0.41 0.14 ± 0.026 0.45 ± 0.093 0.21 ± 0.10 Lungs (D) 0.032 ± 0.0065 2.51 ± 0.72 0.77 ± 0.25 0.042 ± 0.010 0.141 ± 0.036 0.064 ± 0.035 Kidneys (H) 1.06 ± 0.14 2.17 ± 0.32 0.40 ± 0.17 0.48 ± 0.15 2.76 ± 0.34 1.25 ± 0.23 Kidneys (D) 0.4 ± 0.11 1.61 ± 0.22 0.33 ± 0.16 0.11 ± 0.047 0.56 ± 0.13 0.35 ± 0.07 Spleen (H) 0.111 ± 0.012 1.71 ± 0.64 0.44 ± 0.16 0.045 ± 0.007 0.172 ± 0.02 0.112 ± 0.042 Spleen (D) 0.061 ± 0.015 1.93 ± 0.61 0.47 ± 0.13 0.018 ± 0.004 0.072 ± 0.02 0.037 ± 0.007 Liver§ (H) 0.46 ± 0.12 Liver§ (D) 0.32 ± 0.06
