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Journal of Nuclear Medicine

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OtherCLINICAL INVESTIGATIONS

Chromogranin A Assay and 131I-MIBG Scintigraphy for Diagnosis and Follow-Up of Pheochromocytoma

Michèle d’Herbomez, Valérie Gouze, Damien Huglo, Marie Nocaudie, François Pattou, Charles Proye, Jean-Louis Wémeau and Xavier Marchandise
Journal of Nuclear Medicine July 2001, 42 (7) 993-997;
Michèle d’Herbomez
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Valérie Gouze
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Damien Huglo
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Marie Nocaudie
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François Pattou
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Charles Proye
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Jean-Louis Wémeau
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Xavier Marchandise
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    FIGURE 1.

    Distribution of CgA levels in pheochromocytoma group (A) before surgery and after surgery, in refuted pheochromocytoma group (B), and in control group (C).

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    FIGURE 2.

    Distribution of CgA levels, of normetanephrine urinary levels (NormetaN), and of metanephrine urinary metabolites (MetaN) in pheochromocytoma group (A; n = 41) and in refuted pheochromocytoma group (B; n = 17).

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    TABLE 1

    CgA Levels in Different Groups

    GroupnCgA level (ng/mL)P*
    MeanSDRange
    Pheochromocytoma4163285339–3,8400.001
    Refuted pheochromocytoma3954.53022–162NS
    Control9850.712.333–105—
    • ↵* Comparison with control group.

    • NS = not statistically significant.

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    TABLE 2

    Index Values for Different Cutoff Levels of CgA

    GroupCutoff CgA level (ng/mL)Sensitivity (%)Specificity (%)PPV (%)NPV (%)
    Pheochromocytoma vs. control10090.299.097.396.1
    11090.2100.0100.096.1
    Pheochromocytoma vs. refuted pheochromocytoma10090.292.392.590.0
    11090.294.994.790.3
    • PPV = positive predictive value; NPV = negative predictive value.

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    TABLE 3

    Concordance Between MIBG Scintigraphy Results and CgA Level

    GroupMIBG+/ CgA+MIBG+/ CgA−MIBG−/ CgA+MIBG−/ CgA−
    Pheochromocytoma
        Before surgery32232
        After surgery00211
    Refuted pheochromocytoma00134
    • + = positive; − = negative.

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Journal of Nuclear Medicine
Vol. 42, Issue 7
July 1, 2001
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Chromogranin A Assay and 131I-MIBG Scintigraphy for Diagnosis and Follow-Up of Pheochromocytoma
Michèle d’Herbomez, Valérie Gouze, Damien Huglo, Marie Nocaudie, François Pattou, Charles Proye, Jean-Louis Wémeau, Xavier Marchandise
Journal of Nuclear Medicine Jul 2001, 42 (7) 993-997;

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Chromogranin A Assay and 131I-MIBG Scintigraphy for Diagnosis and Follow-Up of Pheochromocytoma
Michèle d’Herbomez, Valérie Gouze, Damien Huglo, Marie Nocaudie, François Pattou, Charles Proye, Jean-Louis Wémeau, Xavier Marchandise
Journal of Nuclear Medicine Jul 2001, 42 (7) 993-997;
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