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Journal of Nuclear Medicine

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OtherBASIC SCIENCE INVESTIGATIONS

Comparison of Sestamibi, Tetrofosmin, and Q12 Retention in Porcine Myocardium

Ichiro Matsunari, Felix Haas, Ngoc T.B. Nguyen, Günther Reidel, Ingo Wolf, Reingard Senekowitsch-Schmidtke, Gerhard Stöcklin and Markus Schwaiger
Journal of Nuclear Medicine May 2001, 42 (5) 818-823;
Ichiro Matsunari
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Felix Haas
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Ngoc T.B. Nguyen
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Günther Reidel
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Ingo Wolf
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Reingard Senekowitsch-Schmidtke
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Gerhard Stöcklin
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Markus Schwaiger
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  • FIGURE 1.
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    FIGURE 1.

    Experimental procedures. LAD = left descending coronary artery.

  • FIGURE 2.
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    FIGURE 2.

    Example of absolute myocardial retention of sestamibi and tetrofosmin plotted against microsphere-determined flow (A), and example of absolute myocardial retention of sestamibi and Q12 plotted against microsphere-determined flow (B).

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    FIGURE 3.

    Absolute myocardial retention of sestamibi and tetrofosmin plotted against microsphere-determined flow for group 1 pigs (A), and that of sestamibi and Q12 for group 2 pigs (B).

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    TABLE 1

    Linear Regression Analysis of Retention Vs. Myocardial Blood Flow for Low and High Flow Ranges

    GroupFlow range
    Low (≤1.0 mL/g/min)High (>1.0 mL/g/min)
    Group 1
       Sestamibi slope0.3070 ± 0.01028 (<0.0001)0.1738 ± 0.006233 (<0.0001)
       Tetrofosmin slope0.05974 ± 0.009525 (<0.0001)0.005058 ± 0.005291 (0.3412)
       Are the slopes different? (P)<0.0001<0.0001
    Group 2
       Sestamibi slope0.3670 ± 0.01326 (<0.0001)0.08652 ± 0.003768 (<0.0001)
       Q12 slope0.02401 ± 0.006020 (<0.0001)0.01223 ± 0.001190 (<0.0001)
       Are the slopes different? (P)<0.00010.05571
    • Values in parentheses indicate probability values testing presence of slope different from 0 for relationship between retention and flow.

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Journal of Nuclear Medicine
Vol. 42, Issue 5
May 1, 2001
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Comparison of Sestamibi, Tetrofosmin, and Q12 Retention in Porcine Myocardium
Ichiro Matsunari, Felix Haas, Ngoc T.B. Nguyen, Günther Reidel, Ingo Wolf, Reingard Senekowitsch-Schmidtke, Gerhard Stöcklin, Markus Schwaiger
Journal of Nuclear Medicine May 2001, 42 (5) 818-823;

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Comparison of Sestamibi, Tetrofosmin, and Q12 Retention in Porcine Myocardium
Ichiro Matsunari, Felix Haas, Ngoc T.B. Nguyen, Günther Reidel, Ingo Wolf, Reingard Senekowitsch-Schmidtke, Gerhard Stöcklin, Markus Schwaiger
Journal of Nuclear Medicine May 2001, 42 (5) 818-823;
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