High-Dose Treatment with 186Re-HEDP or 153Sm-EDTMP Combined with Amifostine in a Rabbit Model | Journal of Nuclear Medicine

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FIGURE 1.
ROI positions on whole-body scintigram of rabbit from posterior view 3 h after injection of 1,000 MBq ¹⁵³Sm-EDTMP.
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FIGURE 2.
Chemical structure of amifostine and its active metabolite, the free thiol WR-1065.

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TABLE 1
Decrease in Platelet and Leukocyte Counts After Treatment with ¹⁸⁶Re-HEDP
Platelets Leukocytes
ReA ReC ReA ReC
36.8 54.0 56.4 75.5
37.8 57.3 63.3 78.8
34.4 59.7 80.5 67.4
40.3 68.8 82.9 70.0
35.9 65.2 86.3 70.9
33.9 62.9 82.2 72.2
35.5 ± 2.4* 61.3 ± 5.4* 75.3 ± 12.3^† 72.5 ± 4.1^†
↵*Significant difference (P < 0.001).
↵^†No significant difference (P > 0.05).
Data are percentage of initial values. Final row is mean ± SD for 6 rabbits.
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TABLE 2
Decrease in Platelet and Leukocyte Counts After Treatment with ¹⁵³Sm-EDTMP
Platelets Leukocytes
SmA SmC SmA SmC
25.8 35.5 79.4 52.5
36.4 34.8 76.6 60.3
36.8 53.8 66.1 55.6
41.6 68.1 52.8 56.8
29.6 60.6 80.4 52.3
48.9 60.8 62.2 62.1
36.5 ± 8.3* 52.3 ± 14.0* 69.2 ± 10.8^† 56.6 ± 4.0^†
↵*Significant difference (P < 0.05).
↵^†Significant difference (P < 0.05).
Data are percentage of initial values. Final row is mean ± SD for 6 rabbits.

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