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Journal of Nuclear Medicine

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11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux

Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike and Robert B. Innis
Journal of Nuclear Medicine March 2008, DOI: https://doi.org/10.2967/jnumed.107.047308
Sami S. Zoghbi
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Jeih-San Liow
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Fumihiko Yasuno
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Jinsoo Hong
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Edward Tuan
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Neva Lazarova
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Robert L. Gladding
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Victor W. Pike
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Robert B. Innis
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Journal of Nuclear Medicine: 66 (5)
Journal of Nuclear Medicine
Vol. 66, Issue 5
May 1, 2025
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11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Mar 2008, DOI: 10.2967/jnumed.107.047308

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11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux
Sami S. Zoghbi, Jeih-San Liow, Fumihiko Yasuno, Jinsoo Hong, Edward Tuan, Neva Lazarova, Robert L. Gladding, Victor W. Pike, Robert B. Innis
Journal of Nuclear Medicine Mar 2008, DOI: 10.2967/jnumed.107.047308
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  • Retrospective Analysis of P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier in Humans
  • Behavioral Effects and Central Nervous System Levels of the Broadly Available {kappa}-Agonist Hallucinogen Salvinorin A Are Affected by P-Glycoprotein Modulation In Vivo
  • A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier
  • Avoiding Barriers to PET Radioligand Development: Cellular Assays of Brain Efflux Transporters
  • Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET
  • PET Imaging of the Gastrointestinal Absorption of Orally Administered Drugs in Conscious and Anesthetized Rats
  • N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier
  • P-Glycoprotein Function at the Blood-Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide
  • Human Brain Imaging and Radiation Dosimetry of 11C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein
  • Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
  • P-Glycoprotein Function at the Blood-Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys
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