Abstract
P554
Introduction: Accurate diagnosis and prognostic risk assessment are paramount to reducing mortality of malignant melanoma (MM) patients, while conventional methods have their own demerits. 18F-PFPN PET, a melanin-targeted imaging modality, showed superior diagnostic utility in MM. To investigate the prognostic value of 18F-PFPN PET in MM patients, and seek the independent prognostic factors for progression-free survival (PFS) and overall survival (OS).
Methods: We retrospectively reviewed the patients who underwent 18F-PFPN PET images from January 2021 to February 2022. PET parameters (normalized maximum standardized uptake value [SUVmax], whole-body melanotic tumoral volume [WBMTV], whole-body lesions melanin [WBTLM]) were collected, as well as clinical characteristics and follow-up. Kaplan-Meier and Cox regression analysis were performed to evaluate patients’ prognosis and determine potential independent predictors.
Results: A total of 54 patients (30 males and 24 females, median age, 57.13 ± 9.87 years) were included. The mean follow-up period was 11.61 ± 4.72 months. During the follow-up period, 9 cases died and 22 cases progressed. The overall median survival time was 16.55 months (95%CI: 15.08–18.02). In Kaplan-Meier study, patients who had a higher normalized SUVmax, WBMTV, and WBTLM exhibited shorter PFS and OS time than the lower ones (log-rank P < 0.05). In univariable analysis, TNM stages, normalized SUVmax, WBMTV, and WBTLM were significantly associated with the cumulative incidence of PFS and OS (P < 0.05). In multivariable analysis, normalized SUVmax was the independent risk factor of PFS and OS combing with clinical characteristics. Besides, Kaplan-Meier curves showed that patients without PET assessable lesions have longer PFS and OS time while without statistical significance (PFS, P = 0.087; OS, P = 0.143).
Conclusions: 18F-PFPN had a profound significance in prognosticating MM. The patients with higher normalized SUVmax of 18F-PFPN are prone to have poorer prognoses.
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