Promise and challenges in RIT: Kraeber-Bodéré and colleagues offer perspective on current clinical uses and potential future applications of radioimmunotherapy and preview an article on bispecific radioimmunoconjugate therapy in this issue of JNM.
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Pretargeted immuno-PET: Marquez and Lapi briefly review the advantages of bispecific targeting with antibodies, including reduction of exposure to normal organs and reliable retention of tumor accumulation, and discuss a related article in this issue of JNM.
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Shortened 18F-FMISO dynamic PET: Grkovski and colleagues investigate the feasibility of kinetic modeling using shortened acquisition times in 18F-fluoromisonidazole dynamic PET, with the goal of expediting clinical implementation.
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Post-RT PET in nasopharyngeal carcinoma: Zhou and colleagues report on the results of a metaanalysis of published data on the value of 18F-FDG PET/CT in identification of residual or recurrent nasopharyngeal carcinoma.
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PEM interpretation for reduced counts: MacDonald and colleagues study the effects of reduced 18F-FDG injection activity on interpretation of positron emission mammography images and compare interpretations at 2 postinjection acquisition times.
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PERCIST and survival after radioembolization: Michl and colleagues evaluate the prognostic accuracy of established PET response criteria in patients with liver metastases from pancreatic cancer after treatment with 90Y microspheres.
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18F-FAZA PET in pancreatic cancer: Metran-Nascente et al. describe a minimally invasive technique for measuring the oxygenation status of pancreatic cancers.
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68Ga-PSMA PET for lung metastases: Pyka and colleagues explore the use of a 68Ga-labeled prostate-specific membrane antigen agent in PET differentiation between pulmonary metastases and primary lung cancer in patients with prostate cancer.
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Sympathetic activation and BAT: Bahler and colleagues examine the question of whether lower brown adipose tissue activity in older or overweight individuals can be explained by a lower sympathetic nervous system response to cold.
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SPECT vs. CT in acute chest pain: Nabi and colleagues compare the performance of SPECT stress myocardial perfusion, optimized with stress-only imaging, with that of cardiac CT angiography in patients with acute chest pain.
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Nicorandil MPI and prognosis: Fukushima and colleagues describe a technique using nicorandil stress myocardial perfusion SPECT with this hybrid adenosine triphosphate–sensitive potassium channel opener to predict major adverse cardiac events in patients with acute ischemic heart failure.
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Genetics and brain 18F-FDG uptake: Watanabe and colleagues study 18F-FDG uptake on PET in monozygotic and dizygotic twins and controls to elucidate the relative effects of genetic and environmental influences on regional brain glucose metabolism.
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99mTc-CXCL8 and inflammation in IBD: Aarntzen and colleagues investigate the accuracy of 99mTc-CXCL8 SPECT in detection and localization of disease activity in a prospective series of patients with inflammatory bowel disease.
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Human dosimetry of 68Ga-DOTA-E[c(RGDfK)]2: López-Rodríguez and colleagues use whole-body PET to detail the biodistribution of and radiation dose from this radiolabeled dimeric αvβ3 integrin ligand as a potential agent for imaging tumor angiogenesis.
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PET/MR and neurodegeneration: Tahmasian and colleagues determine whether multimodal imaging based on the network degeneration hypothesis can distinguish between different neurodegenerative syndromes.
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Pulsatile-flow ventilation PET/CT: Prior and colleagues explore the performance of a novel system for reducing respiratory motion in PET/CT in inducing sustained apnea in spontaneously breathing patients.
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PET/CT and PET/MR in cancer: Spick and colleagues provide an educational overview of PET/MR scanner designs, including technical and operational issues, and review the literature to determine whether cancer assessments are improved with this hybrid modality.
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Affibody radionuclide pretargeting: Altai and colleagues describe mouse studies testing the hypothesis that Affibody-based bioorthogonal chemistry–mediated pretargeting can reduce radiometal accumulation in kidneys, creating preconditions for palliative radionuclide therapy.
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64Cu-ATSM and pO2: Li and colleagues compare the accumulation and distribution of 64Cu-ATSM and 64CuCl2 in different tumor tissues using partial pressure of oxygen probe measurements to determine relative robustness as hypoxia markers.
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Dual-receptor targeted RIT: Razumienko and colleagues describe the results of translational studies treating tumors coexpressing human epidermal growth factor receptor–2 and epidermal growth factor receptor with radiolabeled bispecific radioimmunoconjugates.
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Pretargeted PET and CA19.9: Houghton and colleagues detail a pretargeting strategy that exploits the bioorthogonal reaction between transcyclooctene and tetrazine to overcome time and other challenges in PET imaging of cancers expressing carbohydrate antigen 19.9.
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PET and integrin α5β1 and αvβ3: Notni and colleagues report on the use of click chemistry in developing 68Ga-aquibeprin, which is combined with 68Ga-avebetrin to produce complementary PET mapping of integrins α5β1 and αvβ3.
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Imaging experimental arthritis: Terry and colleagues test fibroblast activation protein, macrophages, and integrin αvβ3 as targets for 111In-labeled imaging of response to etanercept in arthritic mice.
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PET/MR tumor modeling: Divine and colleagues create a Gaussian mixture modeling pipeline to structure complementary information from 18F-FDG PET and diffusion-weighted MR imaging, separating the tumor microenvironment into compartments and longitudinally following individual compartment development.
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VEGF-A–targeted fluorescence endoscopy: Tjalma and colleagues validate fluorescent tracers targeted to vascular endothelial growth factor A and epidermal growth factor receptor during ex vivo colonoscopy with a near-infrared endoscopy platform.
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213Bi micro-SPECT imaging: de Swart and colleagues describe the 213Bi imaging capabilities of the Versatile Emission Computed Tomograph for simultaneous preclinical imaging of both SPECT and PET isotopes over a wide photon energy range of 25–600 keV.
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- © 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.