Immune checkpoint inhibitors 1 result in impressive clinical responses 2 , 3 , 4 , 5 , but
optimal results will require combination with each other 6 and other therapies. This raises …

Background Preoperative identification of tumour type could have important implications for
the choice of treatment for renal cancers. Antibody cG250 reacts against carbonic anhydrase-…

Importance Individualized cancer treatment, tailored to a particular patient and the tumor’s
biological features (precision oncology), requires a detailed knowledge of tumor biology. …

Patients with metastatic or unresectable (advanced) pheochromocytoma and paraganglioma
(PPGL) have poor prognoses and few treatment options. This multicenter, phase 2 trial …

BACKGROUND. Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad
population of patients with ovarian cancer; however, resistance caused by low enzyme …

Humanized A33 (huA33) is a promising monoclonal antibody that recognizes A33 antigen,
which is present in more than 95% of colorectal cancers and in normal bowel. In this study, …

Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of
mammalian biology 1 . In addition, homeostatic pathways allow organisms to protect their core …

Positron emission tomography (PET) is a radiotracer imaging method that yields quantitative
images of regional in vivo biology and biochemistry. PET, now used in conjunction with …

Hürthle cell carcinoma is an uncommon and occasionally aggressive differentiated thyroid
cancer associated with increased mortality compared with other differentiated thyroid …

The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial
field of view, can image the major body organs simultaneously with higher sensitivity than …