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Research ArticlePhysics and Instrumentation
Open Access

PennPET Explorer: Human Imaging on a Whole-Body Imager

Austin R. Pantel, Varsha Viswanath, Margaret E. Daube-Witherspoon, Jacob G. Dubroff, Gerd Muehllehner, Michael J. Parma, Daniel A. Pryma, Erin K. Schubert, David A. Mankoff and Joel S. Karp
Journal of Nuclear Medicine January 2020, 61 (1) 144-151; DOI: https://doi.org/10.2967/jnumed.119.231845
Austin R. Pantel
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Varsha Viswanath
2Department of Biomedical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania; and
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Margaret E. Daube-Witherspoon
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Jacob G. Dubroff
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Gerd Muehllehner
3KAGE Medical, Wayne, Pennsylvania
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Michael J. Parma
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Daniel A. Pryma
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Erin K. Schubert
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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David A. Mankoff
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Joel S. Karp
1Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
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Abstract

The PennPET Explorer, a prototype whole-body imager currently operating with a 64-cm axial field of view, can image the major body organs simultaneously with higher sensitivity than that of commercial devices. We report here the initial human imaging studies on the PennPET Explorer, with each study designed to test specific capabilities of the device. Methods: Healthy subjects were imaged with FDG on the PennPET Explorer. Subsequently, clinical subjects with disease were imaged with 18F-FDG and 68Ga-DOTATATE, and research subjects were imaged with experimental radiotracers. Results: We demonstrated the ability to scan for a shorter duration or, alternatively, with less activity, without a compromise in image quality. Delayed images, up to 10 half-lives with 18F-FDG, revealed biologic insight and supported the ability to track biologic processes over time. In a clinical subject, the PennPET Explorer better delineated the extent of 18F-FDG–avid disease. In a second clinical study with 68Ga-DOTATATE, we demonstrated comparable diagnostic image quality between the PennPET scan and the clinical scan, but with one fifth the activity. Dynamic imaging studies captured relatively noise-free input functions for kinetic modeling approaches. Additional studies with experimental research radiotracers illustrated the benefits from the combination of large axial coverage and high sensitivity. Conclusion: These studies provided a proof of concept for many proposed applications for a PET scanner with a long axial field of view.

  • PET
  • whole-body imager
  • human imaging

Footnotes

  • Published online Sep. 27, 2019.

  • © 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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Journal of Nuclear Medicine: 61 (1)
Journal of Nuclear Medicine
Vol. 61, Issue 1
January 1, 2020
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PennPET Explorer: Human Imaging on a Whole-Body Imager
Austin R. Pantel, Varsha Viswanath, Margaret E. Daube-Witherspoon, Jacob G. Dubroff, Gerd Muehllehner, Michael J. Parma, Daniel A. Pryma, Erin K. Schubert, David A. Mankoff, Joel S. Karp
Journal of Nuclear Medicine Jan 2020, 61 (1) 144-151; DOI: 10.2967/jnumed.119.231845

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PennPET Explorer: Human Imaging on a Whole-Body Imager
Austin R. Pantel, Varsha Viswanath, Margaret E. Daube-Witherspoon, Jacob G. Dubroff, Gerd Muehllehner, Michael J. Parma, Daniel A. Pryma, Erin K. Schubert, David A. Mankoff, Joel S. Karp
Journal of Nuclear Medicine Jan 2020, 61 (1) 144-151; DOI: 10.2967/jnumed.119.231845
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Keywords

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