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Meeting ReportMolecular Targeting Probes - Radioactive and Nonradioactive

Production of 99Mo-99mTc by using spallation neutron

Naruto Takahashi, Kozi Nakai, Atsushi Shinohara, Jun Htazawa, Masanobu Nakamura, Mitsuhiro Fukuda, Kichiji Hatanaka, Yasumasa Morikawa, Masaaki Kobayashi and Asaki Yamamoto
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 1475;
Naruto Takahashi
1Graduate School of Science, Osaka University, Toyonaka, Japan
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Kozi Nakai
1Graduate School of Science, Osaka University, Toyonaka, Japan
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Atsushi Shinohara
1Graduate School of Science, Osaka University, Toyonaka, Japan
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Jun Htazawa
2Graduate School of Medicine, Osaka University, Suita, Japan
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Masanobu Nakamura
3Research Center for Nuclear Physics, Osaka University, Ibaraki, Japan
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Mitsuhiro Fukuda
3Research Center for Nuclear Physics, Osaka University, Ibaraki, Japan
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Kichiji Hatanaka
3Research Center for Nuclear Physics, Osaka University, Ibaraki, Japan
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Yasumasa Morikawa
4Fujifilm RI Pharma Co., Ltd., Sammu, Japan
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Masaaki Kobayashi
4Fujifilm RI Pharma Co., Ltd., Sammu, Japan
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Asaki Yamamoto
4Fujifilm RI Pharma Co., Ltd., Sammu, Japan
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Abstract

1475

Objectives The 99mTc is one of necessary radioisotopes which is used most worldwide in the radioisotope examination today. However, the most are made with nuclear reactors, and understock by the deterioration of a used nuclear reactor is pointed out so far. Using cyclotrons, production of the 99mTc by the 100Mo(p,2n)99mTc and 100Mo(p,d)99Mo-99mTc reactions has been tried until now.

Methods We produced the 99mTc by the 100Mo(n, 2n)99Mo-99mTc reaction using spallation neutron which was produced by using 400 MeV proton from ring cyclotron at the Research Center for Nuclear Physics, Osaka University. A combination of chemical separation and nuclear reaction by spallation neutron using the 400 MeV proton from the cyclotron allowed production of Tc -99m necessary for radioisotope examination. We examined various metal targets to get most suitable spallation neutron flux. Further, some molybdenum targets were irradiated for the chemical separation of technetium from the target.

Results The irradiated molybdenum target was dissolved into aqueous solution. Tc-99m was separated by precipitation of molybdenum, and further impurities were removed by ion exchange chromatography. As a result of having irradiated natural molybdenum in spallation neutron by the proton of 400MeV from the cyclotron, the radioactivity of provided 99Mo-99mTc was 3MBq/gμAh.

Conclusions We produced the 99Mo-99mTc which radioisotope examination could use using narural molybdenum target. In addition, the impurities which occurred by spallation neutron reaction were removed by chemical separation. We shall discuss the yields of spallation neutron, produced radioactivity of 99Mo-99mTc and the removal of impurities by the chemical separation in the lecture

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Journal of Nuclear Medicine
Vol. 53, Issue supplement 1
May 2012
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Production of 99Mo-99mTc by using spallation neutron
Naruto Takahashi, Kozi Nakai, Atsushi Shinohara, Jun Htazawa, Masanobu Nakamura, Mitsuhiro Fukuda, Kichiji Hatanaka, Yasumasa Morikawa, Masaaki Kobayashi, Asaki Yamamoto
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 1475;

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Production of 99Mo-99mTc by using spallation neutron
Naruto Takahashi, Kozi Nakai, Atsushi Shinohara, Jun Htazawa, Masanobu Nakamura, Mitsuhiro Fukuda, Kichiji Hatanaka, Yasumasa Morikawa, Masaaki Kobayashi, Asaki Yamamoto
Journal of Nuclear Medicine May 2012, 53 (supplement 1) 1475;
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