Development and Preclinical Evaluation of [64Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics

Xiaoyan Li; You Zhang; Jason C. Mixdorf; Qianyun Wu; Sophia J. Lee; Jonathan W. Engle; Todd E. Barnhart; Shannon C. Kenney; Lixin Rui; Weijun Wei; Weibo Cai

doi:10.2967/jnumed.124.268835

Research ArticleBasic Science Investigation

Development and Preclinical Evaluation of [⁶⁴Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics

Xiaoyan Li, You Zhang, Jason C. Mixdorf, Qianyun Wu, Sophia J. Lee, Jonathan W. Engle, Todd E. Barnhart, Shannon C. Kenney, Lixin Rui, Weijun Wei and Weibo Cai

Journal of Nuclear Medicine April 2025, 66 (4) 552-558; DOI: https://doi.org/10.2967/jnumed.124.268835

Xiaoyan Li

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

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You Zhang

2Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

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Jason C. Mixdorf

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

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Qianyun Wu

2Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

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Sophia J. Lee

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

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Jonathan W. Engle

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

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Todd E. Barnhart

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

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Shannon C. Kenney

3Department of Oncology, University of Wisconsin–Madison, Madison, Wisconsin;

4Department of Medicine, University of Wisconsin–Madison, Madison, Wisconsin; and

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Lixin Rui

4Department of Medicine, University of Wisconsin–Madison, Madison, Wisconsin; and

5Carbone Cancer Center, University of Wisconsin–Madison, Madison, Wisconsin

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Weijun Wei

2Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;

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Weibo Cai

1Departments of Radiology and Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin;

5Carbone Cancer Center, University of Wisconsin–Madison, Madison, Wisconsin

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Journal of Nuclear Medicine

Vol. 66, Issue 4

April 1, 2025

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Development and Preclinical Evaluation of [⁶⁴Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics

Xiaoyan Li, You Zhang, Jason C. Mixdorf, Qianyun Wu, Sophia J. Lee, Jonathan W. Engle, Todd E. Barnhart, Shannon C. Kenney, Lixin Rui, Weijun Wei, Weibo Cai

Journal of Nuclear Medicine Apr 2025, 66 (4) 552-558; DOI: 10.2967/jnumed.124.268835

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Development and Preclinical Evaluation of [⁶⁴Cu]Cu-NOTA-ABDB6: A CD70 and Albumin Dual-Binding Tracer with Improved Pharmacokinetics

Xiaoyan Li, You Zhang, Jason C. Mixdorf, Qianyun Wu, Sophia J. Lee, Jonathan W. Engle, Todd E. Barnhart, Shannon C. Kenney, Lixin Rui, Weijun Wei, Weibo Cai

Journal of Nuclear Medicine Apr 2025, 66 (4) 552-558; DOI: 10.2967/jnumed.124.268835

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Keywords

CD70
immuno-PET
64Cu
lymphomas
albumin-binding domain
ABD

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