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Journal of Nuclear Medicine Vol. 45 No. 2 176-182
© 2004 by Society of Nuclear Medicine

Clinical Investigations

Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease

Riemer H.J.A. Slart, MD1,2, Jeroen J. Bax, MD, PhD3, Richard M. de Jong, MD, PhD4, Jaep de Boer, MD, PhD1, Hildo J. Lamb, PhD5, Piet H. Mook, PhD6, Antoon T.M. Willemsen, PhD2, Willem Vaalburg, PhD2, Dirk J. van Veldhuisen, MD, PhD4 and Pieter L. Jager, MD, PhD1,2

1 Department of Nuclear Medicine, Groningen University Medical Center, Groningen, The Netherlands
2 PET-Center, Groningen University Medical Center, Groningen, The Netherlands
3 Department of Cardiology, University Medical Center, Leiden, The Netherlands
4 Department of Cardiology, Groningen University Medical Center, Groningen, The Netherlands
5 Department of Radiology, University Medical Center, Leiden, The Netherlands
6 Department of Radiology, Groningen University Medical Center, Groningen, The Netherlands

The aim of this study was to compare left ventricular (LV) volumes and regional wall motion determined by PET with those determined by the reference technique, cardiovascular MRI. Methods: LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were measured and regional wall motion was scored in 38 patients with chronic coronary artery disease by both gated 18F-FDG PET and MRI. A 9-segment model was used for PET and MRI to assess regional wall motion. Results: Good correlations were observed between MRI and gated PET for all parameters (r values ranging from 0.91 to 0.96). With PET, there was a significant but small underestimation of LVEDV and LVEF. Mean ± SD LVEDV, LVESV, and LVEF for MRI were 131 ± 57 mL, 91 ± 12 mL, and 33% ± 12%, respectively, and those for gated PET were 117 ± 56 mL, 85 ± 51 mL, and 30% ± 11%, respectively. For regional wall motion, an agreement of 85% was found, with a {kappa}-statistic of 0.79 (95% confidence interval, 0.70–0.89; SE, 0.049). Conclusion: LV volumes, LVEF, and regional wall motion can be assessed with gated 18F-FDG PET and correlate well with these parameters assessed by MRI.

Key Words: gated 18F-FDG PET • left ventricular volumes • left ventricular ejection fraction • regional wall motion • MRI




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