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The Journal of Nuclear Medicine Vol. 34 No. 2 222-227
© 1993 by Society of Nuclear Medicine
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Technetium-99m-Tetrofosmin as a New Radiopharmaceutical for Myocardial Perfusion Imaging

J. Duncan Kelly, Alan M. Forster, Brian Higley, Colin M. Archer, Fong S. Booker, Lewis R. Canning, K. Wai Chiu, Barbara Edwards, Harjit K. Gill, Mary McPartlin, Katharine R. Nagle, Ian A. Latham, Roger D. Pickett, Anthony E. Storey and Peter M. Webbon

Pharmaceuticals Research and Development, Amersham International plc, Buckinghamshire, United Kingdom
School of Chemistry, University of North London, London, United Kingdom
Department of Medicine, Royal Veterinary College, North Mymms, Hatfield, Hertfordshire, United Kingdom

Correspondence: For correspondence or reprints contact: J.D. Kelly, Pharmaceuticals Research and Development, Amersham International plc, White Lion Road, Amersham, Buckinghamshire HP7 9LL, United Kingdom.

ABSTRACT

A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.




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