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Correction for Attenuation in Technetium-99m-HMPAO SPECT Brain Imaging

Department of Nuclear Medicine, St. Joseph's Health Centre, Lawson Research Institute and The University of Western Ontario, London, Ontario, Canada
Department of Nuclear Medicine, Royal Victoria Hospital and McGill University, Montreal, Quebec, Canada

Correspondence: For reprints contact: Brad Kemp, MSc, Nuclear Medicine Department, St. Joseph's Health Centre, 268 Grosvenor St., London, Ontario, Canada N6A 4V2.

ABSTRACT

We present a correction technique that uses the effective bone and tissue attenuation coefficients to compensate ^99mTc-HMPAO brain SPECT projections for attenuation. Transverse images of a human skull filled with a uniform mixture of ^99mTc and gelatin have a greater count density at the center with respect to the periphery when corrected for attenuation with the effective water/tissue coefficient of 0.12 cm^–1. An attenuation coefficient of 0.09 cm^–1 produces uniform images at the expense of a reduced count density. Additional experiments with phantoms wrapped with aluminum (to simulate bone) indicate that the greater count density at the image center is a result of increased attenuation at the edges of the projections where there is a greater path length through the aluminum (or bone). SPECT projections explicitly corrected for both bone and soft-tissue attenuation result in images of improved uniformity and increased count density.

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