Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist
Z Szabo, PF Kao, HD Burns… - The Journal of Nuclear …, 1998 - search.proquest.com
Antagonists of the angiotensin II AT1 receptor subtype have been recently introduced for
treatment of arterial hypertension and for pharmacological studies of these receptors. The …
treatment of arterial hypertension and for pharmacological studies of these receptors. The …
Characterization of the binding of [3H] L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT1) antagonist radioligand.
TB Chen, VJ Lotti, RS Chang - Molecular pharmacology, 1992 - ASPET
[3H] L-158,809, a new potent and AT1-selective nonpeptide angiotensin II receptor
antagonist, bound saturably and reversibly to rat adrenal membranes. Scatchard and Hill …
antagonist, bound saturably and reversibly to rat adrenal membranes. Scatchard and Hill …
[125I] EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor
AT Chiu, DE McCall, WA Roscoe - Biochemical and biophysical research …, 1992 - Elsevier
Abstract [125 I] EXP985 is the first nonpeptide radioligand with high specific activity for the
AT 1 angiotensin receptor. The biochemical and pharmacological profiles of this ligand were …
AT 1 angiotensin receptor. The biochemical and pharmacological profiles of this ligand were …
Carbon‐11 labeling of a potent, nonpeptide, at1‐selective angiotensin‐II receptor antagonist: MK‐996
WB Mathews, HD Burns, RF Dannals… - Journal of Labelled …, 1995 - Wiley Online Library
Abstract [α‐11C] Benzoyl chloride was synthesized and purified by normal phase
HPLC.[11C] MK‐996 ([11C] N‐[[4′[(2‐ethyl‐5, 7‐dimethyl‐3H‐imidazo [4, 5‐b] pyridin‐3 …
HPLC.[11C] MK‐996 ([11C] N‐[[4′[(2‐ethyl‐5, 7‐dimethyl‐3H‐imidazo [4, 5‐b] pyridin‐3 …
Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes
LL Chang, WT Ashton, KL Flanagan… - Journal of medicinal …, 1995 - ACS Publications
In order to blockthe effects induced bythe interactions between angiotensin II (All) and both
ATi and AT2 receptors, we have pursued the discovery of orally active non-peptide All …
ATi and AT2 receptors, we have pursued the discovery of orally active non-peptide All …
Binding of KRH‐594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors
Y Inada, T Nakane*, S Chiba - Fundamental & Clinical …, 2002 - Wiley Online Library
We studied the binding properties of KRH‐594, a new selective antagonist of angiotensin II
(AII) type 1 (AT1) receptors, to rat liver membranes and to recombinant AT1 and AT2 …
(AII) type 1 (AT1) receptors, to rat liver membranes and to recombinant AT1 and AT2 …
Synthesis and evaluation of a 11C‐labelled angiotensin II AT2 receptor ligand
Three 11C‐radiolabelled high‐affinity nonpeptide AT2 receptor‐selective ligands were
synthesized and one of these was evaluated as positron emission tomography (PET) tracer …
synthesized and one of these was evaluated as positron emission tomography (PET) tracer …
In vitro pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors
RSL Chang, VJ Lotti, TB Chen, SS O'Malley… - European journal of …, 1995 - Elsevier
L-163,017 (6-[benzoylamino]-7-methyl-2-propyl-3-[[2′-(N-(3-methyl-1-butoxy)
carbonylaminosulfonyl)[1, 1′]-biphenyl-4-yl] methyl]-3H-imidazo [4, 5-b] pyridine) inhibited …
carbonylaminosulfonyl)[1, 1′]-biphenyl-4-yl] methyl]-3H-imidazo [4, 5-b] pyridine) inhibited …
Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potential
Apart from antagonising 'classical'cardiovascular AT1 receptor-mediated effects, stimulation
of AT2 receptors has additionally been demonstrated in vitro and in vivo to induce neuronal …
of AT2 receptors has additionally been demonstrated in vitro and in vivo to induce neuronal …
Development of [11C] L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging
TG Hamill, HD Burns, RF Dannals, WB Mathews… - Applied radiation and …, 1996 - Elsevier
[11C] L-159,884 ([11C] N-[[4′[(2-ethyl-5, 7-dimethyl-3H-imidazo [4, 5-b] pyridin-3-yl)
methyl][1, 1′-biphenyl]-2-yl] sulfonyl]-4-methoxybenzamide) and [11C] L-162, 574 ([11C] N …
methyl][1, 1′-biphenyl]-2-yl] sulfonyl]-4-methoxybenzamide) and [11C] L-162, 574 ([11C] N …