Molecular imaging of fibroblast activity after myocardial infarction using a 68Ga-labeled fibroblast activation protein inhibitor, FAPI-04

Z Varasteh, S Mohanta, S Robu… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Heart failure remains a major source of late morbidity and mortality after myocardial
infarction (MI). The temporospatial presence of activated fibroblasts in the injured …

Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using 68Ga-FAPI-04

S Notohamiprodjo, SG Nekolla, S Robu… - Journal of Nuclear …, 2022 - Elsevier
Our previous study has demonstrated the feasibility of noninvasive imaging of fibroblast
activation protein (FAP)-expression after myocardial infarction (MI) in MI-territory in a rat …

Visualization of fibroblast activation after myocardial infarction using 68Ga-FAPI PET

L Kessler, J Kupusovic, J Ferdinandus… - Clinical Nuclear …, 2021 - journals.lww.com
Aims The aim of this retrospective analysis was to examine the pattern of cardiac 68 Ga-
fibroblast-activation protein-α inhibitor (FAPI) uptake in patients after acute myocardial …

Cardiac fibroblast activation in patients early after acute myocardial infarction: integration with MR tissue characterization and subsequent functional outcome

J Diekmann, T Koenig, JT Thackeray… - Journal of Nuclear …, 2022 - Soc Nuclear Med
After acute myocardial infarction (AMI), fibroblast activation protein (FAP) upregulation
exceeds the infarct region. We sought further insights into the physiologic relevance by …

Relationship between cardiac fibroblast activation protein activity by positron emission tomography and cardiovascular disease

MB Heckmann, F Reinhardt, D Finke… - Circulation …, 2020 - Am Heart Assoc
Background: FAP (fibroblast activation protein) plays an important role in cardiac wound
healing and remodeling. Although initially developed as a theranostic ligand for …

68Ga-FAPI PET visualize heart failure: from mechanism to clinic

W Song, X Zhang, SK He, Y Gai, C Qin, F Hu… - European Journal of …, 2023 - Springer
Purpose Heart failure (HF) is a chronic progressive clinical syndrome associated with
structural and/or functional heart abnormalities. Active fibroblasts and ventricular …

Fibroblast activation protein imaging in reperfused ST-elevation myocardial infarction: comparison with cardiac magnetic resonance imaging

B Xie, J Wang, XY Xi, X Guo, BX Chen, L Li… - European Journal of …, 2022 - Springer
Purpose The aim of this study was to explore the correlation of 18 F-labeled fibroblast
activation protein inhibitor (FAPI) and cardiovascular magnetic resonance (CMR) …

[HTML][HTML] Molecular imaging of fibroblast activation protein after myocardial infarction using the novel radiotracer [68Ga] MHLL1

LBN Langer, A Hess, Z Korkmaz, J Tillmanns… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Myocardial infarction (MI) evokes an organized remodeling process
characterized by the activation and transdifferentiation of quiescent cardiac fibroblasts to …

Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury/remodeling

J Siebermair, MI Köhler, J Kupusovic… - Journal of Nuclear …, 2021 - Elsevier
Background Fibroblast activation protein (FAP) as a specific marker of activated fibroblasts
can be visualized by positron emission tomography (PET) using Ga-68-FAP inhibitors …

Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction

J Tillmanns, D Hoffmann, Y Habbaba… - Journal of molecular and …, 2015 - Elsevier
Introduction Fibroblast activation protein α (FAP) is a membrane-bound serine protease
expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after …