The 18-kDa mitochondrial translocator protein in human gliomas: an 11C-(R) PK11195 PET imaging and neuropathology study
Z Su, F Roncaroli, PF Durrenberger… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The 18-kDa mitochondrial translocator protein (TSPO) is upregulated in high-grade
astrocytomas and can be imaged by PET using the selective radiotracer 11C-(R) PK11195 …
astrocytomas and can be imaged by PET using the selective radiotracer 11C-(R) PK11195 …
The 18-kDa mitochondrial translocator protein in gliomas: from the bench to bedside
K Janczar, Z Su, I Raccagni, A Anfosso… - Biochemical Society …, 2015 - portlandpress.com
The 18-kDa mitochondrial translocator protein (TSPO) is known to be highly expressed in
several types of cancer, including gliomas, whereas expression in normal brain is low. TSPO …
several types of cancer, including gliomas, whereas expression in normal brain is low. TSPO …
TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma
NL Albert, M Unterrainer, DF Fleischmann… - European journal of …, 2017 - Springer
Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
upregulated in gliomas. 18 F-GE-180 is a novel 3rd generation TSPO receptor ligand with …
TSPO as a target for glioblastoma therapeutics
The translocator protein (TSPO) is an 18-kDa five-transmembrane protein, which is primarily
found in the outer mitochondrial membrane. Levels of this protein are up-regulated in the …
found in the outer mitochondrial membrane. Levels of this protein are up-regulated in the …
TSPO deficiency induces mitochondrial dysfunction, leading to hypoxia, angiogenesis, and a growth-promoting metabolic shift toward glycolysis in glioblastoma
Background The ligands of mitochondrial translocator protein (TSPO) have been widely
used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in …
used as diagnostic biomarkers for glioma. However, the true biological actions of TSPO in …
Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma
NL Albert, DV Nelwan, DF Fleischmann… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The 18-kDa translocator protein (TSPO) is gaining recognition as a relevant target in
glioblastoma imaging. However, data on the potential prognostic value of TSPO PET …
glioblastoma imaging. However, data on the potential prognostic value of TSPO PET …
The translocator protein (TSPO): a novel target for cancer chemotherapy
CJD Austin, J Kahlert, M Kassiou… - The international journal of …, 2013 - Elsevier
The translocator protein (TSPO) is an 18kDa transmembrane protein primarily found in the
outer mitochondrial membrane where it forms a key part of the mitochondrial permeability …
outer mitochondrial membrane where it forms a key part of the mitochondrial permeability …
[HTML][HTML] Classical and novel TSPO ligands for the mitochondrial TSPO can modulate nuclear gene expression: implications for mitochondrial retrograde signaling
N Yasin, L Veenman, S Singh, M Azrad, J Bode… - International Journal of …, 2017 - mdpi.com
It is known that knockdown of the mitochondrial 18 kDa translocator protein (TSPO) as well
as TSPO ligands modulate various functions, including functions related to cancer. To study …
as TSPO ligands modulate various functions, including functions related to cancer. To study …
Concentration, distribution, and influence of aging on the 18 kDa translocator protein in human brain: Implications for brain imaging studies
Positron emission tomography (PET) imaging of the translocator protein (TSPO) is widely
used as a biomarker of microglial activation. However, TSPO protein concentration in human …
used as a biomarker of microglial activation. However, TSPO protein concentration in human …
TSPO PET, tumour grading and molecular genetics in histologically verified glioma: a correlative 18F-GE-180 PET study
M Unterrainer, DF Fleischmann, F Vettermann… - European journal of …, 2020 - Springer
Background The 18-kDa translocator protein (TSPO) is overexpressed in brain tumours and
represents an interesting target for glioma imaging. 18 F-GE-180, a novel TSPO ligand, has …
represents an interesting target for glioma imaging. 18 F-GE-180, a novel TSPO ligand, has …