1590 Objectives Her-2/neu protein over expression has been identified in 10%~ 34% of
invasive breast cancers. Trastuzumab (Herceptin) is a humanized IgG1 monoclonal …

2126 Objectives: Her-2/neu protein over expression has been identified in 10%~ 34% of
invasive breast cancers. Trastuzumab (Herceptin) is a humanized IgG1 monoclonal …

2105 Objectives: Human epidermal growth factor receptor 2 (Her-2/neu) protein is a kind of
transmembrane tyrosine kinase receptor found on the surface of breast cells, involving in …

Objective To evaluate the ability of trastuzumab (Herceptin) Fab, labelled with 99m Tc
through introduced hydrazinenicotinamide (HYNIC) functionalities, to image HER2/neu …

INTRODUCTION: Trastuzumab (Herceptin), a humanized IgG1 monoclonal antibody
directed against the extracellular domain of the HER2 protein, acts as an immunotherapeutic …

Overexpression of human epidermal growth factor receptor 2 (HER2) plays important roles
in tumorigenesis and tumor progression in breast cancer. Nuclear imaging of HER2 …

Purpose The novel molecular imaging probe 99m Tc-HYNIC-H10F was developed for
patient screening and efficacy monitoring of trastuzumab therapy by SPECT imaging of …

The amplification of HER2 gene has been described in several tumor types, mainly breast
cancer with a subsequent increase in HER2 protein expression. Trastuzumab is a …

490 Objectives: Herceptin is an anti HER2 antibody and often used for the treatment of
HER2 primary and metastatic disease. Lu-177 herceptin may prove as a potential …

98 Objectives The purpose of this study was to explore the potential of a low dose rate alpha-
particle emitting radioimmunoconjugate; 227 Th-trastuzumab (Herceptin), as a novel …