Sensitive, specific, and noninvasive detection of angiogenesis would be helpful in
discovering new strategies for the treatment of cardiovascular diseases. Recently, we …

Cardiovascular disease is the leading cause of death worldwide. PET has the potential to
provide information on the biology and metabolism of atherosclerotic plaques. Natriuretic …

Atrial natriuretic peptide has been recently discovered to have anticancer effects via
interaction with cell surface natriuretic peptide receptor A (NPRA) and natriuretic peptide …

Purpose To assess the physicochemical properties, pharmacokinetic profiles, and in vivo
positron emission tomography (PET) imaging of natriuretic peptide clearance receptors …

Nanoparticles have been assessed in preclinical models of atherosclerosis for detection of
plaque complexity and treatment. However, their successful clinical translation has been …

The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide
receptor A (NPR-A), has been reported to be expressed in lung cancer, prostate cancer and …

Abstract Background Chemokine receptor 5 (CCR5) plays an important role in
atherosclerosis. Our objective was to develop a SPECT tracer targeting CCR5 for imaging …

Rationale: A noninvasive tool allowing the detection of vulnerable atherosclerotic plaques is
highly needed. By combining nanomolar affinities and fast blood clearance, nanobodies …

Background CD13 is selectively upregulated in angiogenic active endothelium and can
serve as a target for molecular imaging tracers to non-invasively visualise angiogenesis in …

Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of
tumor neovasculature, and may serve as a promising target for cancer diagnosis and …