Disulfiram inhibits defluorination of [18F] FCWAY, reduces radioactivity in bone, and enhances visualization of binding to serotonin 5-HT1A receptors in human brain
YH Ryu, JS Liow, S Zoghbi, M Fujita, J Collins… - 2007 - Soc Nuclear Med
202 Objectives:[18 F] Trans-4-fluoro-N-2-[4-(2-methoxyphenyl) piperazin-1-yl] ethyl]-N-(2-
pyridyl) cyclohexanecarboxamide ([18 F] FCWAY) is a PET radioligand for 5-HT 1A …
pyridyl) cyclohexanecarboxamide ([18 F] FCWAY) is a PET radioligand for 5-HT 1A …
Disulfiram inhibits defluorination of 18F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in …
YH Ryu, JS Liow, S Zoghbi, M Fujita… - Journal of Nuclear …, 2007 - Soc Nuclear Med
18F-trans-4-Fluoro-N-2-[4-(2-methoxyphenyl) piperazin-1-yl] ethyl]-N-(2-pyridyl)
cyclohexanecarboxamide (18F-FCWAY) is a PET radioligand for imaging serotonin 5 …
cyclohexanecarboxamide (18F-FCWAY) is a PET radioligand for imaging serotonin 5 …
PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole
DN Tipre, SS Zoghbi, JS Liow, MV Green… - Journal of nuclear …, 2006 - Soc Nuclear Med
18F-FCWAY (18F-trans-4-fluoro-N-(2-[4-(2-methoxyphenyl) piperazin-1-yl) ethyl]-N-(2-
pyridyl) cyclohexanecarboxamide) is useful in clinical research with PET for measuring …
pyridyl) cyclohexanecarboxamide) is useful in clinical research with PET for measuring …
Inhibition of in vivo defluorination of [18F]FCWAY in rat
DN Tipre, SS Zoghbi, JS Liow… - Journal of Cerebral …, 2005 - journals.sagepub.com
Objectives [18F] FCWAY is used in human subjects as a radioligand for PET imaging of
brain 5-HT1A receptors, but suffers from significant defluorination and troublesome skull …
brain 5-HT1A receptors, but suffers from significant defluorination and troublesome skull …
First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors
AT Hillmer, DW Wooten, AK Bajwa… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The serotonin-1A (5-HT1A; 5-HT is 5-hydroxytryptamine) receptor is implicated in an array of
neurologic and psychiatric disorders. Current PET radioligands targeting 5-HT1A receptors …
neurologic and psychiatric disorders. Current PET radioligands targeting 5-HT1A receptors …
The Pyridinyl-6 Position of WAY-100635 as a site for radiofluorination—Effect on 5-HT1A receptor radioligand behavior in vivo
JA McCarron, VW Pike, C Halldin, J Sandell… - Molecular Imaging & …, 2004 - Elsevier
PURPOSE: We aimed to evaluate radiofluorination at the pyridinyl-6 position of the selective
5-HT1A receptor antagonist, WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl) piperazinyl) ethyl)) …
5-HT1A receptor antagonist, WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl) piperazinyl) ethyl)) …
Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate
N Saigal, R Pichika, B Easwaramoorthy… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Serotonin 5-HT1A receptors have been implicated in disorders of the central nervous system
and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of …
and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability of …
Serotonin competition with the new 5-HT1A receptor PET radiotracer: 18F-mefway
N Saigal, R Pichika, B Easwaramoorthy, D Collins… - 2006 - Soc Nuclear Med
1151 Objectives: Changes in serotonin levels in the brain have proved difficult to measure
using PET radiotracers. Competition of endogenous serotonin (fenfluramine-induced …
using PET radiotracers. Competition of endogenous serotonin (fenfluramine-induced …
Fenfluramine mediated blood flow changes confound the effect of 5-HT on [18F] FPWAY, a 5-HT1A receptor ligand
E Jagoda, L Lang, K McCullough, C Contoreggi… - 2006 - Soc Nuclear Med
1150 Objectives: Developing a PET imaging agent to monitor changes in 5-HT 1A receptor
(5-HT 1A R) density or occupancy in vivo would aid in understanding the pathophysiology of …
(5-HT 1A R) density or occupancy in vivo would aid in understanding the pathophysiology of …
Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging
G Becker, J Colomb, V Sgambato-Faure… - European journal of …, 2015 - Springer
Abstract Purpose Brain serotonin 6 receptor (5-HT 6) is one of the most recently identified
serotonin receptors. It is a potent therapeutic target for psychiatric and neurological …
serotonin receptors. It is a potent therapeutic target for psychiatric and neurological …