P-glycoprotein in the blood–brain barrier (BBB) has been found to be associated with
several types of neurologic damage. 11C-Verapamil has been used for in vivo imaging of P …

P-glycoprotein (P-gp) is an ATP-dependent efflux transporter located at the blood–brain
barrier (BBB), involved in the transport of a variety of neurotoxic substances out of the brain …

Diminished P-glycoprotein (P-gp)-mediated transport across the Blood–brain barrier may
play an important role in several neurodegenerative disorders. In previous studies, a …

Background Numerous knockout mouse studies have revealed that P‐glycoprotein (P‐gp)
significantly limits drug distribution across the mouse blood‐brain barrier (BBB). To …

There is evidence that P-glycoprotein (P-gp) in the blood–brain barrier (BBB) may be
involved in the aetiology of neurological disorders. For quantification of P-gp function in …

Introduction P-glycoprotein (P-gp) is one of the most studied efflux transporters at the blood-
brain barrier. It plays an important role in brain homeostasis by protecting the brain from a …

P-glycoprotein (P-gp) plays a pivotal role in limiting the penetration of xenobiotic compounds
into the brain at the blood–brain barrier (BBB), where its expression increases with …

P-glycoprotein is a protective efflux transporter at the blood–brain barrier showing altered
function in many neurological disorders. The purpose of this study was to validate [18F] …

Introduction Positron emission tomography (PET) with [11 C] verapamil, either in racemic
form or in form of the (R)-enantiomer, has been used to measure the functional activity of the …

We used positron emission tomography (PET) to evaluate the contribution of P‐glycoprotein
(P‐gp), present at the human blood–brain barrier (BBB), to regional drug distribution in the …