The potential of trastuzumab Fab-DTPA as a vehicle molecule for theranostic application in HER2 receptor expressing cancers
548 Introduction: The trastuzumab (MW 141kDa) is monoclonal antibody against HER2
receptor protien. We demonstrated the feasibility of Ga-68 Trastuzumab Fab (45kDa) for …
receptor protien. We demonstrated the feasibility of Ga-68 Trastuzumab Fab (45kDa) for …
Abstract B043: Radiolabelled Trastuzumab Fab as a theranostic agent for HER2 expressing breast cancer
Breast cancer is the most common cause of mortality among women worldwide. Among all
subtypes, HER2-positive breast cancers are highly aggressive and have poor prognosis …
subtypes, HER2-positive breast cancers are highly aggressive and have poor prognosis …
Development 68Ga trastuzumab Fab and bioevaluation by PET imaging in HER2/neu expressing breast cancer patients
Methods Fab has been generated by papain digestion and conjugated with the bifunctional
chelating agent NOTA. The SDS-PAGE and MALDI-TOF were used to see the integrity of …
chelating agent NOTA. The SDS-PAGE and MALDI-TOF were used to see the integrity of …
80P radiolabelled trastuzumab Fab as a theranostic molecule for HER2 positive breast cancers
Background Inherited genes, hormonal imbalance, environmental factors, and mutation in
genes are responsible for the development of breast cancer in females. Nowadays, passive …
genes are responsible for the development of breast cancer in females. Nowadays, passive …
The influence of Bz-DOTA and CHX-A″-DTPA on the biodistribution of ABD-fused anti-HER2 Affibody molecules: implications for 114mIn-mediated targeting therapy
V Tolmachev, H Wållberg, K Andersson… - European journal of …, 2009 - Springer
Purpose Affibody molecules represent a novel class of high-affinity agents for radionuclide
tumour targeting. Fusion of the Affibody molecules with an albumin-binding domain (ABD) …
tumour targeting. Fusion of the Affibody molecules with an albumin-binding domain (ABD) …
Imaging HER2 in response to T-DM1 therapy in Breast Cancer Xenografts
932 Objectives: Monoclonal antibodies (mAbs) have become broadly used for treatment of
cancer because they can be engineered to bind specifically to the target and therefore …
cancer because they can be engineered to bind specifically to the target and therefore …
[HTML][HTML] Molecular imaging of HER2 receptor: Targeting HER2 for imaging and therapy in nuclear medicine
D Miladinova - Frontiers in molecular biosciences, 2023 - frontiersin.org
Targeting HER 2 for imaging and therapy in nuclear medicine has been used with a special
emphasis on developing more powerful radiopharmaceuticals. Zirconium-89 plays an …
emphasis on developing more powerful radiopharmaceuticals. Zirconium-89 plays an …
Imaging of HER2-Positive Tumors in NOD/SCID Mice with Pertuzumab Fab-Hexahistidine Peptide Immunoconjugates Labeled with [99mTc]-(I)-Tricarbonyl Complex
VJ Facca, N Al-Saden, A Ku, RM Reilly - Molecular Imaging and Biology, 2021 - Springer
Purpose Molecular imaging of tumor HER2 expression may allow patient selection for HER2-
targeted therapies. Our aim was to introduce hexahistidine (His 6) peptides into pertuzumab …
targeted therapies. Our aim was to introduce hexahistidine (His 6) peptides into pertuzumab …
A kit to prepare 111In-DTPA-trastuzumab (Herceptin) Fab fragments injection under GMP conditions for imaging or radioimmunoguided surgery of HER2-positive …
DA Scollard, C Chan, CMB Holloway… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: The human epidermal growth factor receptor-2 (HER2) gene is amplified
in 25% of invasive breast cancers, and receptor overexpression has been noted in up to …
in 25% of invasive breast cancers, and receptor overexpression has been noted in up to …
Radioimmunotheranostic pair based on the anti-HER2 monoclonal antibody
The oncogene HER2 is an important molecular target in oncology because it is associated
with aggressive disease and the worst prognosis. The development of non-invasive imaging …
with aggressive disease and the worst prognosis. The development of non-invasive imaging …
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