First-in-human study of the 11β-hydroxysteroid dehydrogenase type 1 PET tracer [11C] AS2471907
580 Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
converts cortisone to cortisol. Inhibition of 11β-HSD1 may be a potential therapy for cognitive …
converts cortisone to cortisol. Inhibition of 11β-HSD1 may be a potential therapy for cognitive …
Imaging the enzyme 11β-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
[PDF][PDF] Imaging the enzyme 11b-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …
Synthesis and evaluation of a novel 18F-labeled radiotracer for imaging 11β-HSD1 in the brain
548 Objectives: The enzyme 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) converts
cortisone to cortisol, and controls a key pathway in the regulation of stress. As such it is …
cortisone to cortisol, and controls a key pathway in the regulation of stress. As such it is …
Reduction of 11β-hydroxysteroid dehydrogenase type 1 enzyme levels with increasing body mass index: a Brain PET imaging study
1300 Objectives: The prevalence of obesity in the United States is over 30%, predisposing a
large portion of the population to metabolic diseases. Cortisol, a steroid hormone, promotes …
large portion of the population to metabolic diseases. Cortisol, a steroid hormone, promotes …
First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of
cortisone into the stress hormone cortisol. This first-in-human brain imaging study …
cortisone into the stress hormone cortisol. This first-in-human brain imaging study …
Discovery of a novel radioligand [11C] AS2471907 for PET imaging of the brain 11β-HSD1
A Iwashita, H Fushiki, Y Fujita, Y Murakami, A Noda - 2016 - Soc Nuclear Med
1050 Objectives 11β-HSD1 is enzyme that converts inactive cortisone to active cortisol and
is widely expressed through the adult CNS. The elevation of 11β-HSD1 in brain is observed …
is widely expressed through the adult CNS. The elevation of 11β-HSD1 in brain is observed …
Body mass index and age effects on brain 11β-hydroxysteroid dehydrogenase type 1: a positron emission tomography study
Context Cortisol, a glucocorticoid steroid stress hormone, is primarily responsible for
stimulating gluconeogenesis in the liver and promoting adipocyte differentiation and …
stimulating gluconeogenesis in the liver and promoting adipocyte differentiation and …
A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary …
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of
cortisone to cortisol and controls a key pathway in the regulation of stress. Studies have …
cortisone to cortisol and controls a key pathway in the regulation of stress. Studies have …
Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test–retest study in human brain
K Van Laere, RU Ahmad, H Hudyana… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Phosphodiesterase 10A (PDE10A) plays a central role in striatal signaling and is implicated
in several neuropsychiatric disorders, such as movement disorders and schizophrenia. We …
in several neuropsychiatric disorders, such as movement disorders and schizophrenia. We …