First-in-human study of the 11β-hydroxysteroid dehydrogenase type 1 PET tracer [11C] AS2471907

Y Huang, B Planet, N Nabulsi, S Henry, MQ Zheng… - 2016 - Soc Nuclear Med
580 Objectives The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
converts cortisone to cortisol. Inhibition of 11β-HSD1 may be a potential therapy for cognitive …

Imaging the enzyme 11β-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain

JD Gallezot, N Nabulsi, S Henry… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …

[PDF][PDF] Imaging the enzyme 11b-hydroxysteroid dehydrogenase type 1 with PET: evaluation of the novel radiotracer 11C-AS2471907 in human brain

JD Gallezot, N Nabulsi, S Henry, R Pracitto… - J Nucl …, 2019 - scholar.archive.org
The 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts cortisone to
cortisol and participates in the regulation of glucocorticoid levels in tissues. 11β-HSD1 is …

Synthesis and evaluation of a novel 18F-labeled radiotracer for imaging 11β-HSD1 in the brain

S Li, Z Cai, W Zhang, D Holden, E Baum, N Nabulsi… - 2018 - Soc Nuclear Med
548 Objectives: The enzyme 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) converts
cortisone to cortisol, and controls a key pathway in the regulation of stress. As such it is …

Reduction of 11β-hydroxysteroid dehydrogenase type 1 enzyme levels with increasing body mass index: a Brain PET imaging study

J Bini, A Jastreboff, JD Gallezot, N Nabulsi, A Hillmer… - 2018 - Soc Nuclear Med
1300 Objectives: The prevalence of obesity in the United States is over 30%, predisposing a
large portion of the population to metabolic diseases. Cortisol, a steroid hormone, promotes …

First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1

S Bhatt, NB Nabulsi, S Li, Z Cai… - Journal of Cerebral …, 2020 - journals.sagepub.com
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of
cortisone into the stress hormone cortisol. This first-in-human brain imaging study …

Discovery of a novel radioligand [11C] AS2471907 for PET imaging of the brain 11β-HSD1

A Iwashita, H Fushiki, Y Fujita, Y Murakami, A Noda - 2016 - Soc Nuclear Med
1050 Objectives 11β-HSD1 is enzyme that converts inactive cortisone to active cortisol and
is widely expressed through the adult CNS. The elevation of 11β-HSD1 in brain is observed …

Body mass index and age effects on brain 11β-hydroxysteroid dehydrogenase type 1: a positron emission tomography study

J Bini, S Bhatt, AT Hillmer, JD Gallezot… - Molecular imaging and …, 2020 - Springer
Context Cortisol, a glucocorticoid steroid stress hormone, is primarily responsible for
stimulating gluconeogenesis in the liver and promoting adipocyte differentiation and …

A Novel 18F-Labeled Radioligand for Positron Emission Tomography Imaging of 11β-Hydroxysteroid Dehydrogenase (11β-HSD1): Synthesis and Preliminary …

E Baum, W Zhang, S Li, Z Cai, D Holden… - ACS Chemical …, 2019 - ACS Publications
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of
cortisone to cortisol and controls a key pathway in the regulation of stress. Studies have …

Quantification of 18F-JNJ-42259152, a novel phosphodiesterase 10A PET tracer: kinetic modeling and test–retest study in human brain

K Van Laere, RU Ahmad, H Hudyana… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Phosphodiesterase 10A (PDE10A) plays a central role in striatal signaling and is implicated
in several neuropsychiatric disorders, such as movement disorders and schizophrenia. We …