1205 Objectives The new serotonin transporter (SERT) ligand [C-11] AFM has higher
binding affinity in vitro and displays higher specific binding signals than the current standard …

314 Objectives: The serotonin transporter (SERT) ligand [C-11] AFM in baboons has
produced better specific binding signals than [C-11] DASB (Huang: JCBFM 2002). We …

Alterations of serotonin transporters (SERT) are implicated in a large number of psychiatric
conditions. 11C-(+)-6β-(4-Methylthiophenyl)-1, 2, 3, 5, 6α, 10β-hexahydropyrrolo [2, 1-a] …

468 Objectives:[11 C] AFM is a new radioligand for the serotonin transporter which showed
higher specific binding than [11 C] DASB in nonhuman primate studies. The aim of this study …

The recent introduction of a number of new radiotracers suitable for imaging the serotonin
transporters (SERT) has radically changed the field of SERT imaging. Whereas, until …

A new positron emission tomography (PET) radioligand for the serotonin transporter
(SERT),[11C] 2-[2-[[(dimethylamino) methyl] phenyl] thio]-5-(2-fluoroethyl) phenylamine …

[11C] AFM, or [11C] 2-[2-(dimethylaminomethyl) phenylthio]-5-fluoromethylphenylamine, is a
new positron emission tomography (PET) radioligand with high affinity and selectivity for the …

11C-Labeled 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile (DASB) is a
selective radioligand for the in vivo quantitation of serotonin transporters (SERTs) using …

Methods PET imaging was conducted on the HRRT scanner. A total of eight healthy control
subjects were studied. Among these, six subjects (4 males, 2 females) were scanned two …

388 Objectives: Considerable evidence derived from the study of human postmortem tissue
has convincingly implicated alterations in brain serotonin transporters (SERT) in the …