The primary goal of this study was to assess the suitability of 11C-Pittsburgh compound B
(11C-PiB) blood–brain barrier delivery (K 1) and relative delivery (R 1) parameters as …

In Alzheimer's Disease (AD) dual-tracer positron emission tomography (PET) studies with 2-
[18F]-fluoro-2-deoxy-D-glucose (FDG) and 11C-labelled Pittsburgh Compound B (PIB) are …

PET studies with biomarkers of regional neuronal activity (cerebral glucose metabolism or
blood flow [CBF]) and amyloid-β (Aβ) depositions provide complementary information for the …

Background: We report results of the novel Washout Allometric Reference Method (WARM)
that uses estimates of cerebral blood flow and amyloid load from the same [11C] Pittsburgh …

Surrogates of neuronal activity, typically measured by regional cerebral blood flow (rCBF) or
glucose metabolism, can be estimated from dynamic amyloid PET imaging. Using data for …

The PET tracer 11C-deuterium-L-deprenyl (11C-DED) has been used to visualize activated
astrocytes in vivo in patients with Alzheimer disease (AD). In this multitracer PET study, early …

Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of
brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool …

[11C] UCB-J PET for synaptic vesicle glycoprotein 2 A (SV2A) has been proposed as a
suitable marker for synaptic density in Alzheimer's disease (AD). We compared [11C] UCB-J …

Introduction Dual-biomarker positron emission tomography (PET), providing complementary
information on cerebral blood flow and amyloid-β deposition, is of clinical interest for …

Several methods are in use for analyzing 11C-Pittsburgh compound-B (11C-PiB) data. The
objective of this study was to identify the method of choice for measuring longitudinal …