1263 Objectives: Tryptophan crosses cancer cells through amino acid transporters, and
further undergoes catabolism mainly through intracellular IDO/TDO (indoleamine 2, 3 …

Purpose Fluorine-18 labeled tryptophan analog l-1-[18 F] fluoroethyl-tryptophan (l-1-[18 F]
FETrp) was designed for positron emission tomography (PET) imaging of cancer by dual …

Purpose Tryptophan metabolism via indoleamine 2, 3-dioxygenase (IDO)-mediated
kynurenine pathway plays a role in immunomodulation and has been emerging as a …

Large neutral l-amino acids are substrates of system L amino acid transporters. The level of
one of these, LAT1, is increased in many tumors. Aromatic l-amino acids may also be …

Abstract Introduction [18 F] FDG PET has difficulty distinguishing tumor from inflammation in
the clinic because of the same high uptake in nonmalignant and inflammatory tissue. In …

1188 Objectives Tryptophan is an essential amino acid and over 95% of tryptophan is
metabolized via kynurenine pathway, which is involved in the modulation of immune …

Purpose Preclinical studies showed the tryptophan analog PET radiotracer 1-(2-18F-
fluoroethyl)-L-tryptophan (18F-FETrp) to accumulate in various tumors, including gliomas …

BACKGROUND Abnormal metabolism of tryptophan via the serotonin and kynurenine
pathways plays a key role in multiple disease processes including cancer. Upregulation of …

Abnormal tryptophan metabolism via the kynurenine pathway is involved in the
pathophysiology of a variety of human diseases including cancers. α-11C-methyl-l …

Due to its metabolism via the serotonin and kynurenine pathways, tryptophan plays a key
role in multiple disease processes including cancer. Imaging tryptophan uptake and …