The overexpression of integrin αvβ6 in pancreatic cancer makes it a promising target for
noninvasive PET imaging. However, currently, most integrin αvβ6–targeting radiotracers are …

Accepted: 31 May 2021© The Author (s) 2021 αvβ6-Integrin is exclusively expressed by
epithelial cells and plays an important role for invasion and metastasis of carcinomas. We …

Radiolabeled cyclic arginine-glycine-aspartic (RGD) peptides can be used for noninvasive
determination of integrin αvβ3 expression in tumors. In this study, we performed …

Purpose Our goal was to demonstrate that suitably derivatized monomeric RGD peptide-
based PET tracers, targeting integrin α v β 3, may offer advantages in image contrast, time …

Integrin αvβ6 is a cell surface receptor minimally expressed by healthy tissue but elevated in
lung, colon, skin, ovarian, cervical, and pancreatic cancers. A molecular PET agent for …

Purpose Radiolabeled heterodimeric peptide has emerged as a highly promising targeting
strategy for PET imaging due to their superior properties. RGD and GE11 are two peptides …

Integrin α6 has been considered a promising biomarker, is overexpressed in many tumors,
and plays a vital role in tumor formation, recurrence, and metastasis. In this study, we …

The overexpression of integrin αvβ3 has been linked to tumor aggressiveness and
metastasis in several cancer types. Because of its high affinity, peptides containing the …

Purpose To develop a new probe for the αvβ6-integrin and assess its potential for PET
imaging of carcinomas. Methods Ga-68-Trivehexin was synthesized by trimerization of the …

Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to
malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually …