11C-MC1 has adequate sensitivity to measure low density cyclooxygenase 2 (COX-2) in healthy human brain
X Yan, A Zhang, S Zoghbi, JS Liow, C Morse… - 2021 - Soc Nuclear Med
103 Introduction: Cyclooxygenase enzymes (COX) are important targets for
neuroinflammation. COX-1 is constitutively present at such high density in the brain and …
neuroinflammation. COX-1 is constitutively present at such high density in the brain and …
[HTML][HTML] PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
Abstract Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by
inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several …
inflammation, is a key enzyme catalyzing the rate-limiting step in the synthesis of several …
Novel PET radioligands show that, in rhesus monkeys, COX-1 is constitutively expressed and COX-2 is induced by inflammation
203 Objectives: The cyclooxygenase (COX) system comprises two primary isoforms, COX-1
and COX-2, which regulate the rate-limiting step in the synthesis of prostaglandins and …
and COX-2, which regulate the rate-limiting step in the synthesis of prostaglandins and …
First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain
Purpose This study assessed whether the newly developed PET radioligand [11 C] PS13,
which has shown excellent in vivo selectivity in previous animal studies, could be used to …
which has shown excellent in vivo selectivity in previous animal studies, could be used to …
First-in-human evaluation of 11C-PS13 for imaging cyclooxygenase-1 in brain and peripheral organs
MJ Kim, JH Lee, FJ Anaya, P Singh, J Hong, C Morse… - 2019 - Soc Nuclear Med
321 Objectives: Cyclooxygenase (COX)-1 is constitutively expressed in most organs and
produces prostanoids that mediate physiological functions. However, recent studies suggest …
produces prostanoids that mediate physiological functions. However, recent studies suggest …
Synthesis of PET radioligands as potential probes for imaging COX-2 in neuroinflammation
M Cortes, P Singh, C Morse, S Shrestha, K Jenko… - 2015 - Soc Nuclear Med
1092 Objectives Cyclooxygenase-2 (COX-2) expression is elevated in inflammation.[1] PET
radioligands for imaging COX-2 should prove useful for studying neuroinflammation but …
radioligands for imaging COX-2 should prove useful for studying neuroinflammation but …
A novel PET radioligand,[11C] PS13, successfully images COX-1, a potential biomarker for neuroinflammation.
S Shrestha, P Singh, M Eldridge, M Cortes, R Gladding… - 2016 - Soc Nuclear Med
115 Objectives Cyclooxygenase-1 (COX-1) is mainly located in activated microglia, and is
considered to be an important player in mediating brain inflammation in neuropsychiatric …
considered to be an important player in mediating brain inflammation in neuropsychiatric …
A novel PET probe, 11C-ketoprofen-methyl ester, targeting cyclooxygenase-1 in the brain
M Shukuri, M Takashima-Hirano, K Tokuda… - 2011 - Soc Nuclear Med
224 Objectives Neuroinflammation occurs as a defensive response to pathogenic insult in
brain and plays a crucial role in a variety of neurodegenerative diseases such as …
brain and plays a crucial role in a variety of neurodegenerative diseases such as …
In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester
M Shukuri, M Takashima-Hirano… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Cyclooxygenase (COX)-1 and-2 are prostanoid-synthesizing enzymes that play important
roles in the regulation of neuroinflammation and in the development of neurodegenerative …
roles in the regulation of neuroinflammation and in the development of neurodegenerative …
[HTML][HTML] Progress in PET imaging of neuroinflammation targeting COX-2 enzyme
Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the
pathogenesis of degenerative brain diseases such as Alzheimer's disease (AD), Parkinson's …
pathogenesis of degenerative brain diseases such as Alzheimer's disease (AD), Parkinson's …