Feasibility of single-time-point dosimetry for radiopharmaceutical therapies

X Hou, J Brosch, C Uribe, A Desy… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Because of challenges in performing routine personalized dosimetry in radiopharmaceutical
therapies, interest in single-time-point (STP) dosimetry, particularly using only a single …

Toward single-time-point image-based dosimetry of 177Lu-PSMA-617 therapy

J Brosch-Lenz, A Delker, F Völter… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Radiopharmaceutical therapies (RPTs) with 177Lu-prostate-specific membrane antigen
(PSMA) ligands have demonstrated promising results for the treatment of metastatic …

Optimal sampling schedules for kidney dosimetry based on the hybrid planar/SPECT method in 177Lu‐PSMA therapy

A Rinscheid, P Kletting, M Eiber, AJ Beer… - Medical …, 2019 - Wiley Online Library
Purpose Accurate and precise renal dosimetry during 177Lu‐labeled prostate‐specific
membrane antigen (PSMA) radioligand therapy is crucial for therapy decisions. Sampling …

[HTML][HTML] Patient-specific dosimetry adapted to variable number of SPECT/CT time-points per cycle for Lu-DOTATATE therapy

L Vergnaud, AL Giraudet, A Moreau, J Salvadori… - EJNMMI physics, 2022 - Springer
Background The number of SPECT/CT time-points is important for accurate patient dose
estimation in peptide receptor radionuclide therapy. However, it may be limited by the …

An international study of factors affecting variability of dosimetry calculations, part 1: design and early results of the SNMMI dosimetry challenge

C Uribe, A Peterson, B Van, R Fedrigo… - Journal of Nuclear …, 2021 - Soc Nuclear Med
In this work, we present details and initial results from a 177 Lu dosimetry challenge that has
been designed to collect data from the global nuclear medicine community aiming at …

Individualized dosimetry in patients undergoing therapy with 177Lu-DOTA-D-Phe1-Tyr3-octreotate

M Sandström, U Garske, D Granberg, A Sundin… - European journal of …, 2010 - Springer
Purpose In recent years, targeted radionuclide therapy with [177 Lu-DOTA 0, Tyr 3]
octreotate for neuroendocrine tumours has yielded promising results. This therapy may be …

Theoretical aspects on the use of single-time-point dosimetry for radionuclide therapy

J Gustafsson, J Taprogge - Physics in Medicine & Biology, 2022 - iopscience.iop.org
Objective. This study considers the error distributions for time-integrated activity (TIA) of
single-time-point (STP) methods for patient-specific dosimetry in radionuclide therapy …

Radiation dosimetry in 177Lu-PSMA-617 therapy using a single posttreatment SPECT/CT scan: a novel methodology to generate time-and tissue-specific dose factors

PA Jackson, MS Hofman, RJ Hicks… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Calculation of radiation dosimetry in targeted nuclear medicine therapies is traditionally
resource-intensive, requiring multiple posttherapy SPECT acquisitions. An alternative …

[HTML][HTML] Investigation of image-based lesion and kidney dosimetry protocols for 177Lu-PSMA-I&T therapy with and without a late SPECT/CT acquisition

S Resch, S Takayama Fouladgar, M Zacherl… - EJNMMI physics, 2023 - Springer
Background 177Lu-PSMA therapy has been successfully used to prolong the survival of
patients with metastatic castration-resistant prostate cancer. Patient-specific dosimetry …

[HTML][HTML] Software-assisted dosimetry in peptide receptor radionuclide therapy with 177Lutetium-DOTATATE for various imaging scenarios

D Kupitz, C Wetz, H Wissel, F Wedel, I Apostolova… - PloS one, 2017 - journals.plos.org
In peptide receptor radionuclide therapy (PRRT) of patients with neuroendocrine neoplasias
(NENs), intratherapeutic dosimetry is mandatory for organs at risk (eg kidneys) and tumours …