In vivo evaluation of 11C-preladenant for PET imaging of adenosine A2A receptors in the conscious monkey
X Zhou, R Boellaard, K Ishiwata, M Sakata… - Journal of Nuclear …, 2017 - Soc Nuclear Med
11C-preladenant was developed as a novel PET ligand for the adenosine A2A receptors
(A2ARs). The present study aimed to evaluate the suitability of 11C-preladenant PET for the …
(A2ARs). The present study aimed to evaluate the suitability of 11C-preladenant PET for the …
Initial evaluation of an adenosine A2A receptor ligand, 11C-preladenant, in healthy human subjects
M Sakata, K Ishibashi, M Imai… - Journal of Nuclear …, 2017 - Soc Nuclear Med
11C-preladenant is a selective antagonist for mapping of cerebral adenosine A2A receptors
(A2ARs) by PET. This is a first-in-human study to examine the safety, radiation dosimetry …
(A2ARs) by PET. This is a first-in-human study to examine the safety, radiation dosimetry …
In vivo evaluation of [11C]preladenant positron emission tomography for quantification of adenosine A2A receptors in the rat brain
X Zhou, S Khanapur, JR de Jong… - Journal of Cerebral …, 2017 - journals.sagepub.com
[11C] Preladenant was developed as a novel adenosine A2A receptor positron emission
tomography radioligand. The present study aims to evaluate the suitability of [11C] …
tomography radioligand. The present study aims to evaluate the suitability of [11C] …
Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptors
O Barret, J Hannestad, C Vala, D Alagille… - Journal of Nuclear …, 2015 - Soc Nuclear Med
PET with selective adenosine 2A receptor (A2A) radiotracers can be used to study a variety
of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …
of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …
Preclinical evaluation and quantification of 18F-fluoroethyl and 18F-fluoropropyl analogs of SCH442416 as radioligands for PET imaging of the adenosine A2A …
S Khanapur, A van Waarde, RAJO Dierckx… - Journal of Nuclear …, 2017 - Soc Nuclear Med
The cerebral adenosine A2A receptor is an attractive therapeutic target for neuropsychiatric
disorders. 18F-fluoroethyl and 18F-fluoropropyl analogs of 18F-labeled pyrazolo [4, 3-e]-1 …
disorders. 18F-fluoroethyl and 18F-fluoropropyl analogs of 18F-labeled pyrazolo [4, 3-e]-1 …
[HTML][HTML] Quantitative in vivo imaging of adenosine A2A receptors in the human brain using 11C-SCH442416 PET: A pilot study
ID Grachev, M Doder, DJ Brooks… - Journal of Diagnostic …, 2014 - openmedscience.com
Abstract 11 C-SCH442416 was reported in preclinical studies with rodents and primates to
be the first nonxanthine radioligand suitable for the in vivo imaging of adenosine A 2A …
be the first nonxanthine radioligand suitable for the in vivo imaging of adenosine A 2A …
Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys
O Barret, J Hannestad, D Alagille, C Vala… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Motor symptoms in Parkinson disease (PD) are caused by a loss of dopamine input from the
substantia nigra to the striatum. Blockade of adenosine 2A (A2A) receptors facilitates …
substantia nigra to the striatum. Blockade of adenosine 2A (A2A) receptors facilitates …
In vivo kinetic and steady-state quantification of 18F-CPFPX binding to rat cerebral A1 adenosine receptors: validation by displacement and autoradiographic …
D Elmenhorst, T Kroll, F Wedekind… - Journal of nuclear …, 2013 - Soc Nuclear Med
In vivo imaging of the A1 adenosine receptor (A1AR) using 18F-8-cyclopentyl-3-(3-
fluoropropyl)-1-propylxanthine (18F-CPFPX) and PET has become an important tool for …
fluoropropyl)-1-propylxanthine (18F-CPFPX) and PET has become an important tool for …
A1 adenosine receptor PET using [18F] CPFPX: displacement studies in humans
PT Meyer, D Elmenhorst, A Matusch, O Winz, K Zilles… - Neuroimage, 2006 - Elsevier
BACKGROUND.: Imaging of cerebral A1 adenosine receptors (A1AR) with positron
emission tomography (PET) has recently become available for neurological research. To …
emission tomography (PET) has recently become available for neurological research. To …
Reproducibility of Non-Invasive A1 Adenosine Receptor Quantification in the Rat Brain Using [18F]CPFPX and Positron Emission Tomography
Abstract Purpose The A 1 AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine
([18 F] CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo …
([18 F] CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo …