1452 Objectives: The carbonyl group is one of the most widespread functional groups
present in many bioactive molecules. That makes [11 C] carbon monoxide an attractive …

515 Introduction: Relative to 11 C-methylation, few 11 C-carbonyl-labeled
radiopharmaceuticals have been translated for clinical PET research. We report on 3 new …

The prospects for using carbon-11 labelled compounds in molecular imaging has improved
with the development of diverse synthesis methods, including 11 C-carbonylations and …

Purpose This short review aims to cover the more recent and promising developments of
carbon-11 (11 C) labeling radiochemistry and its utility in the production of novel …

Positron emission tomography (PET) is a non-invasive molecular imaging technique that
has found extensive utility in biomedical research and in drug development. A fundamental …

[11C] carbon monoxide ([11C] CO) is a versatile synthon for radiolabeling of drug‐like
molecules for imaging studies with positron emission tomography (PET). We here report the …

Abstract [11 C] Carbon monoxide is an appealing synthon for introducing carbon-11 at a
carbonyl position (C= O) in a wide variety of chemotypes (eg, amides, ketones, acids, esters …

Translation of carbon-11 labeled PET tracers to clinical settings is currently impeded by the
technical difficulties associated with [11 C] CO 2 conversion into the highly reactive …

181 Objectives: C-11 syntheses of PET imaging agents can be challenging when dealing
with long reaction times due to a 20.4 min half-life. Carbonylation reactions are no …

Cyclotron‐produced carbon‐11 is a highly valuable radionuclide for the production of
positron emission tomography (PET) radiotracers. It is typically produced as relatively …