Detecting Infection and Inflammation with Technetium-99m-Labeled Stealth®Liposomes
Page 1 11. Spencer PD, Roth KS. Effects of succinylacetone on amino acid uptake in the rat …

We have recently developed a procedure to label liposomes containing reduced glutathione
(GSH) with 99mTc using the lipophilic chelator, hexamethylpropyleneamine oxime …

Methods: The biodistributionand imaging characteristicsof differ ent liposomal formulations
labeled with"" Tc were determined in rats with S. aureus infection of the left calf muscle. The …

Abstract Indium-111 (111 In) and technetium-99m (99 Tc m) Stealth R liposomes were
compared with 111 In-and 99 Tc m-labelled white blood cells (WBC) in experimental …

Liposomes encapsulating both glutathione and deferoxamine were labeled with 99mTc-
HMPAO and 111In-oxine at the same time. These dual radiolabeled liposomes were …

Department ofNuclear Medicine, University Hospital Nijmegen, Nijmegen; Department
ofPharmaceutics, Utrecht Institute for Pharmaceutical Science, Utrecht University, Utrecht …

Purpose To investigate the biodistribution and the ability of stealth pH-sensitive liposomes
radiolabelled with 99m Tc to identify inflammatory regions in a rat focal inflammation model …

1111n-labeledPEGyiated (coated with polyethylene glycol) lipo somes was studied in a rat
model. Methods: Indium-ill PEGylated Iipsomes were administered intravenouslyto rats …

Polyethyleneglycol (PEG) liposomes have been shown to be excellent vehicles for
scintigraphic imaging of infection and inflammation in various experimental models. In this …

[99mTc] liposomes (TL) and [111In] WBCs (WBCs) were compared for imaging colitis in
rabbits. At 24 h, liver was the major organ of accumulation (7.8% TL vs 39.7% WBCs) …