68Ga-DOTA-NT-20.3 neurotensin receptor 1 PET imaging as a surrogate for neuroendocrine differentiation of prostate cancer

W Wu, F Yu, P Zhang, T Bu, J Fu, S Ai… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–negative neuroendocrine prostate cancer
(PCa) is a subtype of PCa likely to be lethal, with limited clinical diagnostic and therapeutic …

68Ga-DOTA-NT-20.3 Neurotensin receptor 1 positron emission tomography imaging as a surrogate for neuroendocrine differentiation of prostate cancer

WY Wu, F Yu, PJ Zhang, T Bu, JJ Fu, SY Ai… - Journal of Nuclear …, 2022 - Soc Nuclear Med
PSMA-negative neuroendocrine prostate cancer (NEPC) is likely to be a lethal subtype of
prostate cancer (PCa) with limited clinical diagnostic and therapeutic options. High …

Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use

T He, M Wang, H Wang, H Tan, Y Tang, E Smith… - European journal of …, 2019 - Springer
Introduction Despite recent developments in the diagnosis and treatment of prostate cancer,
the advanced stages still have poor survival rates. This warrants further exploration of …

Preclinical PET Imaging of NTSR-1-Positive Tumors with 64Cu- and 68Ga-DOTA-Neurotensin Analogs and Therapy with an 225Ac-DOTA-Neurotensin Analog

D Li, M Minnix, R Allen, J Bading, J Chea… - Cancer Biotherapy & …, 2021 - liebertpub.com
Background: The aim of the study was to perform PET imaging and radiotherapy with a
novel neurotensin derivative for neurotensin receptor 1 (NTSR-1)-positive tumors in an …

Safety and tolerability of 68Ga-NT-20.3, a radiopharmaceutical for targeting neurotensin receptors, in patients with pancreatic ductal adenocarcinoma: the first in …

M Hodolic, WY Wu, Z Zhao, F Yu, I Virgolini… - European Journal of …, 2021 - Springer
Introduction Over the last decades, multiple peptide receptors were recognized as potential
diagnostic and therapeutic targets in nuclear medicine. 68 Ga-NT-20.3 radiopharmaceutical …

Imaging Neurotensin Receptor in Prostate Cancer With 64Cu-Labeled Neurotensin Analogs

H Deng, H Wang, H Zhang, M Wang… - Molecular …, 2017 - journals.sagepub.com
Introduction: Neurotensin receptor 1 (NTR-1) is expressed and activated in prostate cancer
cells. In this study, we explore the NTR expression in normal mouse tissues and study the …

Novel DOTA-Neurotensin Analogues for 111In Scintigraphy and 68Ga PET Imaging of Neurotensin Receptor-Positive Tumors

F Alshoukr, A Prignon, L Brans, A Jallane… - Bioconjugate …, 2011 - ACS Publications
Overexpression of the high affinity neurotensin receptor 1 (NTSR1), demonstrated in several
human cancers, has been proposed as a new marker for human ductal pancreatic …

Synthesis and Evaluation of 64Cu-DOTA-NT-Cy5.5 as a Dual-Modality PET/Fluorescence Probe to Image Neurotensin Receptor-Positive Tumor

H Deng, H Wang, M Wang, Z Li, Z Wu - Molecular pharmaceutics, 2015 - ACS Publications
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles
in the growth and survival of a variety of tumor types. The aim of this study is to develop a …

Preclinical Evaluation of 68Ga-DOTA-NT-20.3: A Promising PET Imaging Probe To Discriminate Human Pancreatic Ductal Adenocarcinoma from Pancreatitis

A Prignon, C Provost, F Alshoukr… - Molecular …, 2019 - ACS Publications
Neurotensin receptor 1 (NTSR1) is overexpressed in human pancreatic ductal
adenocarcinoma (PDAC). Specific noninvasive positron-emission tomography (PET) …

[PDF][PDF] Evaluation of the neurotensin receptor-1 as target for molecular imaging and radiotherapy of pancreatic and prostate cancer

S Geer - 2018 - opus4.kobv.de
The NTS1 has emerged as an interesting target for molecular imaging and targeted
endoradiotherapy (“theranostics”) due to its overexpression in a variety of tumors, such as …