[PDF][PDF] 99mTc-HYNIC-folate: a novel receptor-based targeted radiopharmaceutical for tumor imaging
W Guo, GH Hinkle, RJ Lee - Journal of Nuclear Medicine, 1999 - Soc Nuclear Med
Division ofPharmaceutics and Pharmaceutical Chemistry and Division ofPharmacy Practice
and Administration, College ofPharmacy, Ohio State University, Columbus, Ohio o@ 14 …
and Administration, College ofPharmacy, Ohio State University, Columbus, Ohio o@ 14 …
Synthesis of [99mTc]DTPA-Folate and Its Evaluation as a Folate-Receptor-Targeted Radiopharmaceutical
CJ Mathias, D Hubers, PS Low… - Bioconjugate …, 2000 - ACS Publications
A DTPA− folate conjugate was radiolabeled with 99mTc by stannous chloride reduction of
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …
Preparation and In Vitro and In Vivo Evaluation of Technetium-99m-Labeled Folate and Methotrexate Conjugates as Tumor Imaging Agents
SM Okarvi, IA Jammaz - Cancer biotherapy & radiopharmaceuticals, 2006 - liebertpub.com
The cell-membrane folic acid (FA) receptors are known to be responsible for cellular
accumulation of FA and FA analogs, such as methotrexate (MTX), and are overexpressed on …
accumulation of FA and FA analogs, such as methotrexate (MTX), and are overexpressed on …
Synthesis and evaluation of 99mTc (CO) 3-DTPA-folate as a folate-receptor-targeted radiopharmaceutical
DP Trump, CJ Mathias, Z Yang, PS Low… - Nuclear medicine and …, 2002 - Elsevier
A folate-receptor-targeted 99mTc-radiopharmaceutical,[99mTc] Tc (CO) 3DTPA-folate, was
prepared by heating [99mTc] Tc (CO) 3 (H2O) 3+ in an aqueous solution of the previously …
prepared by heating [99mTc] Tc (CO) 3 (H2O) 3+ in an aqueous solution of the previously …
SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate
The folate receptor (FR) is overexpressed on epithelial cancers (FR-α) and on activated, but
not resting, macrophages (FR-β) involved in a variety of inflammatory and autoimmune …
not resting, macrophages (FR-β) involved in a variety of inflammatory and autoimmune …
Folate-receptor-targeted radionuclide imaging agents
CY Ke, CJ Mathias, MA Green - Advanced drug delivery reviews, 2004 - Elsevier
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …
Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors
99mTc-technetium (99mTc) and 188Re-rhenium (188Re) represent an interesting pair of
radionuclides for diagnosis and therapy. The aim of this study was to synthesize and …
radionuclides for diagnosis and therapy. The aim of this study was to synthesize and …
Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting
Purpose The folate receptor (FR) is a valuable tumour marker, since it is frequently
overexpressed on various cancer types. The purpose of the present study was to pre …
overexpressed on various cancer types. The purpose of the present study was to pre …
Synthesis and in Vitro/in Vivo Evaluation of Novel 99mTc(CO)3-Folates
Novel organometallic 99mTc (I)-folate derivatives have been synthesized and evaluated in
vitro and in vivo in order to assess the influence of the overall charge of the radioconjugates …
vitro and in vivo in order to assess the influence of the overall charge of the radioconjugates …
99mTc-Ethylenedicysteine-Folate: A New Tumor Imaging Agent. Synthesis, Labeling and Evaluation in Animals
S ligan, DJ Yang, T Higuchi, F Zareneyrizi… - Cancer biotherapy & …, 1998 - liebertpub.com
It is known that membrane folie acid receptors are responsible for cellular accumulation
offolate and folate analogs such as methotrexate and overexpressedon various tumor cells …
offolate and folate analogs such as methotrexate and overexpressedon various tumor cells …