In this study, we investigated the 18F-labeled anti–carcinoembryonic antigen (CEA) T84. 66
diabody, a genetically engineered noncovalent dimer of single-chain variable fragments, for …

Prolonged clearance kinetics have hampered the development of intact antibodies as
imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in …

Radiolabeling monoclonal antibodies (mAbs) allows the evaluation of biodistribution of
constructs in vivo through gamma camera imaging and also permits quantitation of mAb …

A facile and rapid method to label peptides with 18F based on chelation of [18F] AlF has
been developed recently. Since this method requires heating to 100° C, it cannot be used to …

Rapid imaging by antitumor antibodies has been limited by the prolonged targeting kinetics
and clearance of labeled whole antibodies. Genetically engineered fragments with rapid …

Abstract 18F-Fluorodeoxyglucose (18F-FDG) is the most common molecular imaging agent
in oncology, with a high sensitivity and specificity for detecting several cancers. Antibodies …

Pretargeted PET imaging has emerged as an effective strategy for merging the exquisite
selectivity of antibody-based targeting vectors with the rapid pharmacokinetics of …

Radiolabeled anti-carcinoembryonic antigen (CEA) antibodies have the potential to give
excellent images of a wide variety of human tumors, including tumors of the colon, breast …

Reporter gene imaging has great potential for many clinical applications including the
tracking of transplanted cells and monitoring of gene therapy. However, currently available …

@ Cu-BAT-2ff-1A3-F (ab') 2 was optimized to reduce the renal uptake. Methods: The
bifunctionalchelate6-bromoacetamido benzyl-1, 4, 8, 11-tetraazacyclotetradecane-N, N' …