Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R: 4551

V Tolmachev, J Malmberg, C Hofström… - Journal of Nuclear …, 2012 - Soc Nuclear Med
One of the pathways leading to androgen independence in prostate cancer involves
upregulation of insulinlike growth factor type 1 receptor (IGF-1R). Radionuclide imaging of …

[HTML][HTML] Evaluation of 99mTc-ZIGF1R:4551-GGGC affibody molecule, a new probe for imaging of insulin-like growth factor type 1 receptor expression

B Mitran, M Altai, C Hofström, H Honarvar… - Amino acids, 2015 - Springer
Overexpression of insulin-like growth factor-1 receptor (IGF-1R) in several cancers is
associated with resistance to therapy. Radionuclide molecular imaging of IGF-1R …

[99mTc(CO)3]+-(HE)3-ZIGF1R:4551, a new Affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours

A Orlova, C Hofström, J Strand, Z Varasteh… - European journal of …, 2013 - Springer
Purpose Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R)
expression in tumours might be used for selection of patients who would benefit from IGF-1R …

[HTML][HTML] Preclinical Evaluation of a New Format of 68Ga- and 111In-Labeled Affibody Molecule ZIGF-1R:4551 for the Visualization of IGF-1R Expression in …

Y Liu, S Yu, T Xu, V Bodenko, A Orlova, M Oroujeni… - Pharmaceutics, 2022 - mdpi.com
The Insulin-like growth factor-1 receptor (IGF-1R) is a molecular target for several
monoclonal antibodies undergoing clinical evaluation as anticancer therapeutics. The non …

ImmunoSPECT and immunoPET of IGF-1R expression with the radiolabeled antibody R1507 in a triple-negative breast cancer model

S Heskamp, HWM van Laarhoven… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The insulinlike growth factor 1 receptor (IGF-1R) is a new target for the treatment of breast
cancer. Patients with breast cancer lesions that express IGF-1R may benefit from treatment …

Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice …

J Malmberg, A Perols, Z Varasteh, M Altai… - European journal of …, 2012 - Springer
Purpose In disseminated prostate cancer, expression of human epidermal growth factor
receptor type 2 (HER2) is one of the pathways to androgen independence. Radionuclide …

PET imaging of insulin-like growth factor type 1 receptor expression with a 64Cu-labeled Affibody molecule

X Su, K Cheng, Y Liu, X Hu, S Meng, Z Cheng - Amino Acids, 2015 - Springer
The insulin-like growth factor 1 receptor (IGF-1R) serves as an attractive target for cancer
molecular imaging and therapy. Previous single photon emission computerized tomography …

Targeted therapy of osteosarcoma with radiolabeled monoclonal antibody to an insulin-like growth factor-2 receptor (IGF2R)

DS Geller, J Morris, E Revskaya, M Kahn… - Nuclear medicine and …, 2016 - Elsevier
Introduction Osteosarcoma overall survival has plateaued around 70%, without meaningful
improvements in over 30 years. Outcomes for patients with overt metastatic disease at …

Imaging of human epidermal growth factor receptor type 2 expression with 18F-labeled affibody molecule ZHER2: 2395 in a mouse model for ovarian cancer

S Heskamp, P Laverman, D Rosik… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Affibody molecules are small (7 kDa) proteins with subnanomolar targeting affinity. Previous
SPECT studies in xenografts have shown that the Affibody molecule 111In-DOTA-Z HER2 …

Improved in Vivo Targeting Capability and Pharmacokinetics of 99mTc-Labeled isoDGR by Dimerization and Albumin-Binding for Glioma Imaging

H Gao, C Luo, G Yang, S Du, X Li, H Zhao… - Bioconjugate …, 2019 - ACS Publications
Previously, we successfully developed the c (phg-isoDGRk) peptide as a novel integrin
α5β1-targeted SPECT imaging probe 99mTc-HisoDGR for Glioma imaging. However, the …